This article discusses the importance and significance of evidence-based practice (EBP) in nursing. It explains how EBP integrates the best evidence available to guide nurses in their practice with the view of improving the overall patient outcomes. The article also highlights the significance of the PICOT question format and how it helps healthcare professionals to address questions regarding human health and care with a qualitative and quantitative approach. Additionally, it outlines the goals of EBP and how it allows for the assessment of research and clinical guidelines by healthcare professionals on the basis of high-quality research findings.