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Running head: INCOMPLETE DOMINANCE
INCOMPLETE DOMINANCE
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INCOMPLETE DOMINANCE1
Introduction:
Dominance defined as the phenomenon where one variant allele of a gene present in the
chromosome masking the effect of different variable of homologous gene present on another
chromosome (Fishman 2020). The prime reason behind this is that two different variables of
homologous genes on each chromosome are caused by the mutation on the same gene. While
autosomal dominant and x linked dominance is a common form of dominance that influence the
genotype and phenotype of the organization, another form of dominance is incomplete or co-
dominance where a variant partially affects another. One example is Tay-Sachs disease. This
paper aims to explore the incomplete dominance in the following paragraphs.
Discussion:
Kato et al. (2017), incomplete dominance or intermediate inheritance is observed where
the phenotype of heterozygous genotype is diverse from, the phenotype of homologous genotype
where the influence of one variant is observed. Tay - Sachs disease is one of the most prominent
examples of incomplete dominance in humans. Tay Sachs disease is a genetic disorder that
destroys the nerve cells in the spinal and brain of the human being (Barritt et al. 2017). The most
frequent form of the disease is known as infantile Tay–Sachs disease which becomes evident at
the 6 to 8 months. The common symptoms include deafness, progressive blindness, paralysis and
slow growth. The affected infants usually exhibit lose motor skills such as turning over, crawling
and weak muscle movements (Gray-Edwards et al. 2018). The children with the disease usually
experience seizures, hearing and vision loss, loud noise, ataxia and mental illness. It is
particularly more common amongst certain ethnicity, especially African, African American or

INCOMPLETE DOMINANCE2
population from Mediterranean heritage. It is an Autosomal recessive disease where the
incidence rate is approximately 1 individual out of 3000 individuals and highly prevalent in the
Ashkenazi Jewish population. The mutation is also common in certain French Canadian
communities (Seyrantepe et al. 2018). Therefore, individuals having ancestors from the Cajun
community of Louisiana and Certain French Canadian communities in Quebec are considered as
the risk factors for the disease. The blood and gene assessment can be used to confirm the
disease (Gray-Edwards et al. 2018). The common management process is anti-seizure,
respiratory care such as chest physiotherapy and physiotherapy. The most frequent cause of
death is difficulties from lung inflammation such as bronchopneumonia. The preventing
complications include adequate nutrition, hydration, preventing airway obstruction, avoiding
severe constipation with stool softeners or laxatives.
Figure: incomplete dominance