Influence Of Drug Loading, Efficiency And Dissolution

INFLUENCE OF DRUG LOADING, EFFICIENCY AND DISSOLUTION
INFLUENCE OF DRUG LOADING, EFFICIENCY AND DISSOLUTION
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INFLUENCE OF DRUG LOADING, EFFICIENCY AND DISSOLUTION
Executive Summary
Mesopore nano molecules are increasingly used in the field of drug production because of its
high bioavailability, biocompatibility and biodegradability. The drug loading efficiency also
needs a revise because of the higher dosage of drug can harm the body. So, newer innovative
techniques are being developed to improve the stability, dissociation rate of the drug so that
little amount of drug can do the needful without causing any harm to the body. There are also
a few characterizing techniques that confirm the efficacy of these particles and it’s stability.

INFLUENCE OF DRUG LOADING, EFFICIENCY AND DISSOLUTION
Table of Contents
INTRODUCTION......................................................................................................................4
AIM AND OBJECTIVES..........................................................................................................6
RESEARCH QUESTIONS........................................................................................................6
LITERATURE REVIEW...........................................................................................................6
CONCLUSION........................................................................................................................13
REFERENCES.........................................................................................................................15

INFLUENCE OF DRUG LOADING, EFFICIENCY AND DISSOLUTION
INTRODUCTION
Mesoporous particles can be used as a successful drug delivery system. As the
solubility of drugs remains to be very low, patients need to take medication of higher doses to
meet the therapeutic benefits of a drug. A study was conducted to ensure the extent of the
capability of mesoporous silica nanoparticles (MSNPs) as a drug delivery system.
Mesoporous silica nanoparticles are preferred because of their desirable chemical properties
and thermal stability along with their compatibility with biological tissue. The distinctive
structure of the MSNP allows it to deliver drugs effectively by controlling its slow release
into the body’s target site. The physical and chemical properties of the mesoporous silica
such as the pore size, drug loading capacity and porous nature along with surface properties
can be changed by using additives during the development of MSNP. The altered properties
of the surface of MSNP can make it adhesive to the drugs. The application of MSNP includes
diagnosis, drug delivery into the specific target, uptaking cellular substances and monitoring
body fluids (Bharti et al. 2015).
Drugs that are administered orally should have the property to solubilise and be
absorbed by the intestine to show its therapeutic action but about 40% of drugs that are sold
into the market have low solubility and 70-80% of the newly developed drugs are not sold
into the market because they suffer from low solubility (Le et al. 2019). Solid dispersion
systems can address the solubilization of mesoporous material such as silica which performs
effectively in achieving the delivery of drug molecules within their nanopore structure. There
are various techniques to load the drug into the mesoporous silica including solevent-free and
solvent-dependent techniques. Solvent-based methods are easy to use for amorphisation of
the drug into the mesoporous silica where the drug is dissolved in either ethanol or
impregnated with mesoporous silica followed by removal of the solvent by drying. Spray