This research aims to identify the relationship between nursing workload and patient safety. It specifically focuses on the significance of promoting hand hygiene among healthcare professionals for managing and preventing hospital acquired infections. The literature review highlights the importance of hand hygiene in preventing the transmission of infections and the factors that contribute to poor compliance. The research design is a systematic review, and the methodology involves conducting an online search and analyzing the collected data. The study emphasizes the significance of hand hygiene in patient care and the need for healthcare staff to prioritize patient safety.