This comprehensive guide explores the critical concepts of innovation and commercialization, highlighting their importance for organizational success. It delves into the distinctions between invention and innovation, examining how organizational vision, leadership, culture, and teamwork shape these processes. The 4Ps of innovation and the innovation funnel are explained, providing a framework for examining and shaping innovative ideas. The guide also explores frugal innovation, its development, and its application in organizational contexts. The importance of the commercial funnel and the application of new product development (NPD) processing for commercialization are discussed, along with strategies for building an innovation business case and accessing funding. Finally, the guide evaluates various tools for developing, retaining, and protecting knowledge and intellectual property.