Innovations in 3D printing: a 3D overview from optics to organs

Innovations in 3D printing: a 3D overview from
optics to organs
Carl Schubert, 1 Mark C van Langeveld, 2 Larry A Donoso 1
1 Department of
Ophthalmology, Wills Eye
Hospital, Philadelphia,
Pennsylvania, USA
2 Department of Engineering,
University of Utah, Salt Lake
City, Utah, USA
Correspondence to
Dr Larry A Donoso,
Department of Ophthalmology,
Wills Eye Hospital, PO Box
53429, Philadelphia, PA
19105, USA;
[e-mail]
Received 8 October 2013
Accepted 3 November 2013
Published Online First
28 November 2013
To cite: Schubert C, van
Langeveld MC, Donoso LA.
Br J Ophthalmol
2014;98:159–161.
ABSTRACT
3D printing is a method of manufacturing in which
materials, such as plastic or metal, are deposited onto
one another in layers to produce a three dimensional
object, such as a pair of eye glasses or other 3D objects.
This process contrasts with traditional ink-based printers
which produce a two dimensional object (ink on paper).
To date, 3D printing has primarily been used in
engineering to create engineering prototypes. However,
recent advances in printing materials have now enabled
3D printers to make objects that are comparable with
traditionally manufactured items. In contrast with
conventional printers, 3D printing has the potential to
enable mass customisation of goods on a large scale
and has relevance in medicine including ophthalmology.
3D printing has already been proved viable in several
medical applications including the manufacture of
eyeglasses, custom prosthetic devices and dental
implants. In this review, we discuss the potential for 3D
printing to revolutionise manufacturing in the same way
as the printing press revolutionised conventional printing.
The applications and limitations of 3D printing are
discussed; the production process is demonstrated by
producing a set of eyeglass frames from 3D blueprints.
INTRODUCTION
In 1620, the English Philosopher Francis Bacon
articulated that the printing press, firearms and the
nautical compass changed the state of the world
forever and ushered in the modern world.
Ironically, today it is possible to 3D print firearms,
a compass and 3D printers. The Gutenberg print-
ing press could produce an astonishing 3500
printed pages per day. This actually became the
first assembly line leading to mass production. By
the year 1500 over 20 million books were printed. 1
Other printing techniques followed including such
methods as lithography (a stone or plate used to
print a whole page), dot matrix, laser or inkjet
printers (transfers ink to paper), and digital print-
ing (transfers a digital image to a printing surface).
A common feature of all of these methods is that
the final image is a two dimensional image.
In the early 1980s Charles Hull invented 3D
printing2 which he described as stereolithography
(STL) or the ‘printing’ of successive layers of mater-
ial on top of each other to create a 3D object. The
STL may specify information about the object to be
printed such as its colour, texture, layer thickness,
etc. A large number of such files are available com-
mercially. To demonstrate this new technology, STL
files were used to ‘print’ a pair of conventional eye-
glass frames (figure 1), an unconventional multicol-
oured statute consisting of a variety of shapes,
angles, curves and intricate details in one layer
(figure 2), a multilayered object consisting of three
separate spheres (figure 3), a 3D printer printed by
a 3D printer (figure 4) and a video demonstrating
3D printing (figure 5).
Another feature of 3D printing involves econ-
omies of scale. While traditional manufacturing
methods are still cheaper for large scale production,
the cost of 3D printing is becoming competitive for
smaller production runs. NASA just produced a
fuel injector for one of their rockets at a third of
the cost and two-thirds of the time compared with
traditional methods and plans to have a 3D printer
on board in their next space flight.3 Furthermore,
Figure 2 Complex multicolored 3D printed sculpture.
Figure 1 3D printed eye glass frames.
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in 3D printing, the cost of the set-up is minimal which allows
for a high degree of customisation, as the cost of the first item is
the same as the last. Hence, 3D printing is ideal for making one
of a kind items at cost-effective prices. For example, it may be
possible using this technique to rapidly screen new potential
therapeutic drugs on 3D printed patient tissue, greatly cutting
production costs and time.
There are many potential uses for 3D printing in medicine,
including ophthalmology, which could have a significant impact
in changing the ways patients are treated for various conditions
in the future. A number of recent reviews have been published
and include 3D printing and culture of cells, blood vessels and
vascular networks,4 bandages,5 bones, 6 ears,7 exoskeletons,8
windpipes,9 dental prosthetics including a jaw bone,10 and
future corneas11 entirely new organs to treat specified diseases
such as diabetes, creating prosthetics that look like the body
part they are replacing or supporting, stem cells, testing of new
drugs using printed tissues, and customised drugs.
In the future, it is possible that pharmaceutical companies
may be replaced by databases of drug compounds which would
be emailed to the pharmacy for pharmacy printing only the
amounts of drugs that are required12 13 Furthermore, it may be
possible that vaccines could be delivered via email to the phar-
macy at point of care, then printed and administered. 13 This
means of drug distribution would radically change the present
delivery methods and would most certainly be less costly. In a
similar manner, it will be possible to print out a patient’s living
tissue as a strip which can then serve as a test site for administer-
ing a variety of medications to find the most efficacious one to
treat for the particular illness. 13 14
3D printing is also being investigated as a potential source to
repair or replace defective organs, such as kidneys, heart or skin.
In addition, it also has the potential to create entirely new organs
which would perform the same biological functions as the dis-
eased, non-functioning organ such as a pancreas in the case of
diabetes.15 This could be a significant advancement in the treat-
ment of disease and to alleviate the shortage of organ transplants,
where currently there are about 120 000 people in the USA who
are waiting for an organ transplant (see www.OPTN.transplant.
hrsa.gov/data). Part of the paradigm in this treatment is that
organ transplantation involves finding a tissue match. This issue
could potentially disappear if organs could be printed and grown
using cells from the patient’s own body.
In summary, 3D printing may be helpful in medicine because
the process could potentially be used to make any kind of
organ. By using seed material from the patient’s own tissue, the
problems of tissue rejection caused by inflammatory responses
including tissue graft versus host rejection from heterologous
tissue sources could be avoided, as well as the necessity for
patients to take lifelong immunosuppressants. Proof of concept
Figure 3 Multiple series of spheres 3D printed inside each other.
Figure 4 3D printer printed by a 3D printer.
Figure 5 QR code. Scan to view video on 3D printing.
160 Schubert C, et al. Br J Ophthalmol 2014;98:159–161. doi:10.1136/bjophthalmol-2013-304446
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