This assignment delves into the epidemiology of opioid overdose deaths in Missouri from 2015 to 2016. It examines both experimental and observational study designs, highlighting a cross-sectional study focused on Kansas City residents and the risks associated with opioid epidemics. Statistical data is presented on mortality rates, target groups (aged 25-44), and incidence, emphasizing that 7 in 10 overdose deaths occur in St. Louis and surrounding counties. The paper concludes by showcasing the severity of the crisis within Missouri.