The assignment consists of five topics: Introduction to Computer Organization and Architecture, Data Representation in Computer Systems. The questions cover various aspects of computer organization and architecture, including characteristics of assembly language, addressing mode techniques, time taken for reaching storage locations, why RAM is not used for permanent storage, and interactions between CPU, RAM, and cache memory. Additionally, topics such as Von Neumann architecture, 2's complement, signed-magnitude binary division, subtraction methods, and binary digits are covered.