Leptin: Production, Regulation, Receptors, Signaling Pathway, and Role in Food Intake and Obesity

ADVANCE SYSTEM
PHSYIOLOGY

Table of content
 Where is your chosen peptide produced?
 What regulates its release?
 Where are the receptors for your chosen peptide located and which cell signaling pathway
is activated following receptor activation (keep this simple).
 How does your chosen peptide regulate food intake?
 Role of leptin in obesity?

Where is your chosen peptide produced?
 Leptin is a 16-kDa peptide hormone which is produced from white adipose tissues from an individual's
body
 It helps in balancing between energy intake and energy utilization by the body.
 This hormone helps in binding to hypothalamic receptors and modulating diet control centres in the
brain of an individual.
 Leptin is encoded by the obese gene.
 It include metabolism, endocrine regulation and immune function.
 The amount of leptin hormone within blood stream is directly proportional to the amount of adipose
tissue.
 The most known as action of the action is known as ARC nuclei, ARC nucleus plays a significant role in
activation of such areas and leads changes including thyroid, gonad and others.