Efficacy of LI85008F in Weight Loss: Research Critique

Running head: RESEARCH CRITIQUE 1
Research Critique
Name
Institution

RESEARCH CRITIQUE 2
Research Critique
Introduction
The number of obese and overweight individuals across the globe has seen a great
increase. The world Health Organization (2014) explains that while the rates of prevalence of
these conditions continue to increase across the globe, the population of obese and overweight
people stands a 1 billion and 300 million respectively. To date, body mass index (BMI) is
considered as one of the most effective techniques of detecting obesity and overweight among
patients (Mistry and Puthussery, 2015). Kelishadi, Haghdoost, Sadeghirad and Khajehkazemi,
(2014) reveal that the two conditions are closely associated with the prevalence of lifestyle
diseases such as cancers, cardiovascular ailments and type 2 diabetes. While conventional
strategies of managing weight are effective, the scholars explain that they are highly expensive
and may lead to the advancement of detrimental effects on the side of the patient. As a
consequence, Dixit, Kamath, Alluri and Davis (2018) advance a research aimed at undertaking a
reevaluation of the effectiveness of LI85008F in fostering weight loss among overweight adults
by adopting a 16-week randomized, double-blind, placebo-controlled clinical study.
According to Dixit et al. (2018) LI85008F is an herbal remedy advanced with the aim of
fostering high quality body weight management through inclusion of clinically and botanically
researched dietary ingredients. The scholars reveal that LI85008F works by provoking lipogenic
factors such as PPARˠ and fostering the inhibition of key processes such as lipogenesis in a
simultaneous way. Ideally, the scholarly material under review proceeded with the primary
objective of exploring the efficacy and levels of tolerability of LI85008F in fostering weight loss
among healthy participants that are overweight. For effective comparison, the researchers
adopted reductions in fat mass, BMI, hip and waist circumferences, serum lipid and ghrelin

RESEARCH CRITIQUE 3
profiles. An analysis of the scholarly material reveals that it attained its desired objectives. For
instance, the scholars take the option of adopting a larger population them administering the
described treatment for a longer period. Such an approach does not only increase the levels of
reliability of the study but also enhances its reliability and ease of making generalizations to
other populations (McNeish and Stapleton, 2016).
Overview and Assessment of the Research Methodology
Participants
The investigation was conducted between 1st June and 15th November 2015. The Krupa
Centre for Diabetes and Obesity, Bengaluru and the Sudeep Diabetes Care Centre, Bengaluru
were adopted as independent institutions to foster the process of recruiting voluntary participants
visiting the outpatient wings. 157 participants were recruited and screened to verify their efficacy
of taking part in the study. Of this population, only 140 were considered based on the set
inclusion criteria.
Inclusion criteria
For inclusion, the respondents adopted for this study needed to be healthy based on their
medical records, aged between 21 and 50 years and free from diabetes mellitus intestinal
illnesses and metabolic bone disease. Further, the participants were required to reveal a BMI
ranging between 27 and 29.9kgm-2. Similarly, the voluntary contributors needed to show that they
were medically fit to undertake the research based on their medical records. Additionally, the
partakers were verified to ensure that they were not affected with conditions such as renal and
cardiovascular diseases as well as abnormal functioning of the liver (Dixit et al., 2018).