Understanding Lung Cancer: Types, Epidemiology, Risk Factors, Symptoms, Historical Development, Current and Future Research, and Social Implications

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Added on  2023/05/28

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This presentation covers the basic concepts of lung cancer, including its types, epidemiology, risk factors, symptoms, historical development, current and future research, and social implications. It also includes noteworthy researches for screening, diagnosis, and prognosis of lung cancer.

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Lung Cancer

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Basic Concepts
The basic concepts that has to be learned to
understand about its conditions are-
What is lung cancer?
Types of lung cancer
The types of lung cancer.
The epidemiology
The risk factors
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What is lung Cancer?
Lung cancer is a malignant
lung tumor that is
characterized by uncontrolled
cell growth in the lung
tissues.
Types of lung cancer-
Non-small cell lung cancer
Small cell lung cancer
Lung metastasis
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Epidemiology
(Canadian cancer society, 2017).

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Risk factors
Some of the risk factors associated with lung
cancer are cigarette smoking.
Exposure to second hand smoke.
Occupational exposures such as (Asbestos,
motor vehicle pollutants and emissions)
Less intake of Beta carotene
Radiations
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Signs and Symptoms
Chest pain
Bloody sputum
Weight loss
Loss of appetite
Unknown fever
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Historical development
Lung cancer was not identified as a disease until 1700
In 1810, the various features of the lung cancer was
identified
The screening tests for lung cancer began in 1950s with
annual chest x-rays or sputum cytology (Canadian cancer
society, 2017).
In 1949 Nitrogen mustard (mechlorethamine) becomes
the first chemotherapy approved by the FDA.
Discovery of the interferon in treating cancer in mice
Introduction of radiotherapy in the year 1960

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Current research
Noteworthy researches for screening lung cancer
early-
Finding a low cost tool for predicting whether
the smoker has a high risk of developing lung
cancer
Testing of the urine, blood and sputum or
exhaled breath
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Current researches
Noteworthy researches for the diagnosis and the
prognosis of the lung cancer
Endobronchial ultrasound biopsy
Biomarkers
Testing of the several tumor markers at the
same time
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Current researches
Positive pleural lavage cytology (presence of cancer cells
in the washings from the lining of the lung and rib cage)
Researches about Metformin (antidiabetic drug)
Immunotherapy
Radiation therapies like proton beam radiation therapy,
image –guided radiation therapy and dose-escalation
therapy
Computed tomography guided
fine needle aspiration cytology
Immunotherapy

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Social implications of cancer research
The social implication may consist of:-
Use of the human specimens
Potential rights and the welfare of the human
participants.
Privacy and confidentiality of the patient
information
Informed consent
Storage of the information for future researches
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Future researches
Robot assisted surgery
Combination of both
immunotherapy and
Chemotherapy.
Use of the monoclonal
antibodies
Robot assisted surgery
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Future researches
Antibody drug conjugates
Cell cycle checkpoint inhibitors
Development of appetite enhancing drugs

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Quiz questions
What is lung cancer? State some of the
common symptoms ?
Name some promising fields of research in
lung cancer treatment?
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References
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Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer. BMC cancer, 16(1), 633.
Cameron, S. J., Lewis, K. E., Beckmann, M., Allison, G. G., Ghosal, R., Lewis, P. D., & Mur, L. A. (2016). The metabolomic detection of lung cancer
biomarkers in sputum. Lung Cancer, 94, 88-95.
Canadian cancer society. (2017). Research in lung cancer. Access date: 1.12.2018. Retrieved from:
http://www.cancer.ca/en/cancer-information/cancer-type/lung/statistics/?region=on
Cancer Genome Atlas Research Network. (2012). Comprehensive genomic characterization of squamous cell lung cancers. Nature, 489(7417),
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Tammemagi, M. C., Schmidt, H., Martel, S., McWilliams, A., Goffin, J. R., Johnston, M. R., ... & Soghrati, K. (2017). Participant selection for lung
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Lancet Oncology, 18(11), 1523-1531.
Tarhini, A. A., Rafique, I., Floros, T., Tran, P., Gooding, W. E., Villaruz, L. C., ... & Gomez Garcia, J. (2017). Phase 1/2 study of rilotumumab (AMG
102), a hepatocyte growth factor inhibitor, and erlotinib in patients with advanced non–small cell lung cancer. Cancer, 123(15), 2936-2944.
Wong, K. M., Ding, K., Li, S., Bradbury, P., Tsao, M. S., Der, S. D., ... & Leighl, N. B. (2017). A Cost-Effectiveness Analysis of Using the JBR. 10-
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