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MECHANICAL CHARACTERISATION OF ELECTROSPUN MEMBRANES FOR THE REPAIR ANDREGENERATION OF PELVIC FLOORAbstract:Pelvic organ prolapse (POP) is one of the most common chronic disorder in women, impacting thequality of life of millions of them worldwide. Since their first introduction, surgical meshes havedramatically transformed POP repair, showing superior anatomic outcomes in comparison to traditionalapproaches. Nevertheless significant progress has been attained, there are still unmet clinical needs interms of biocompatibility, mechanical properties, failure and complication rates. Regarding themechanical behaviour of prosthetic implants for POP repair, this is an important factor in ensuring theirfunctionality and integration into the host tissue. Moreover, matching mechanical properties, mainly ina physiological loading range is a desirable requirement towards reducing clinical complications.The aimof this project is to evaluate the mechanical behaviour of novel electrospun membranes for POP repair,based on the blend of two polymers at different concentrations.The work will be based on the development of an experimental protocol, which will include:uniaxialtension evaluation, cyclic loading, and test of the membranes in dry as well as wet conditions.Overall, the project will be carried out through multiple steps, which are summarised here below:1) analysis of the current literature;2) development of an experimental protocol;3) experimental set-up development and characterisation of the samples;4) analysis of the results;5) discussion and report.Reference:1. Maurer M.M., Röhrnbauer B., Feola A., Deprest J., Mazza E., 2015, Prosthetic Meshes for Repair ofHernia and Pelvic Organ Prolapse: Comparison of Biomechanical Properties, Materials, 8, 2794-2808DOI: 10.3390/ma80527942. Ozog Y., Deprest J., Haest K., Claus F., De Ridder D., Mazza E., 2014, Calculation of membrane tensionin selected sections of the pelvic floor, International Urogynecology Journal, 35, 499-506 DOI:10.1007/s00192-013-2253-13. Maurer, Manfred Matthias. Biomechanical Investigation of the Female Pelvic Region. ETH-Zürich(2015). A review of key challenges of electrospun scaffolds for tissue-engineering applications. SajedehKhorshidi, Atefeh Solouk, Hamid Mirzadeh, Saeedeh Mazinani, Jose M. Lagaron, Shahriar Sharifi, SeeramRamakrishna J Tissue Eng Regen Med. 2016 Sep; 10(9): 715–738. Published online 2015 Jan 26. doi:10.1002/term.197855. Developing Repair Materials for Stress Urinary Incontinence to Withstand Dynamic DistensionChristopher J. Hillary, Sabiniano Roman, Anthony J. Bullock, Nicola H Green, Christopher R. Chapple,Sheila MacNeil Published: March 16, 2016
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