Reasons for Drug Discovery and Development Failure and Innovative Solutions

MEDICAL ASSIGNMENT SOLUTION 1
Medical Assignment Solution
Student’s Name
Institutional Affiliation
Date
City

MEDICAL ASSIGNMENT SOLUTION 2
Table of Contents
1. Executive summary........................................................................ 3
2. Introduction..................................................................................4
3. Main body................................................................................... 4
4. Reasons for Drug discovery and drug development failure...........................6
5. Innovative solutions to increase the success rate of DD/D............................8
6. Conclusion...................................................................................9
7. References...................................................................................10

MEDICAL ASSIGNMENT SOLUTION 3
Executive Summary
The researchers usually discover new drugs via the existing treatments, that have unanticipated
effects on the new technologies. However, these technologies typically creates new ways to
target the medical products to the specific sites in the body, along with several tests of the
molecular compounds. On the other hand, after researchers identifying the compound for
development, they usually collect the information on how it absorbed, distributed, metabolized,
and excreted. The researchers also check for the best dosage, along with the potential benefits
and how to integrate with other drugs. This paper will cover drug discovery and development,
the reasons for high failure rates of drug discovery and drug development. Last but not least, this
paper will cover the innovative solutions that can increase the success rates of drug discovery
and drug development.

MEDICAL ASSIGNMENT SOLUTION 4
Introduction
The process of identifying or designing the lead compounds, which possesses the potential
for drug development is called drug discovery. On the other hand, drug development is defined
as the the process of bringing a new drug to the market the moment the lead compound is
identified through processes such as pre-clinical research lead optimization and clinical trials.
There are different approaches that are usually used in order to identify chemical compounds
which can be developed into drugs. As per the current state of biological and chemical sciences
needed for the pharmaceutical development shows that almost 10000 chemical compounds have
to go through laboratory screening for the new drug to be approved for use by humans. This
paper will therefore highlight the reasons why drug discovery and drug development has high
rate of failure. The paper will also cover the innovative solutions which can help to the rate of
success in drug discovery and drug development.
Body
The drug discovery and development majorly focuses on the strategies, the current
methods, and technologies which are used in early-stage pre-clinical research to discover,
validate, and select drug candidates (Cragg, Newman and Snader, 2014). Pharmaceutical
companies face high costs which are always increasing for drug discovery and development and
aggressive competition from generic drug companies. Andrews (2019, reported the average cost
of getting a drug to market is $2.6 billion, which represents $1.4 billion capitalized a cost, and
$1.2 billion in foregone returns on the amount during the average ten-year approval process.
Harrison (2016) suggest that R&D investment for small-molecule compounds with new
molecular entity (NME) designation is not sustainable, presenting an internal rate of return of
approximately 7.5%, which implies a present negative value of $65 million. Examples from the