Medicinal Cannabis

This article explores the benefits and uses of medicinal cannabis, including its effects on glaucoma, asthma, and insomnia. It also discusses the regulatory implications and potential risks associated with its use. The article provides an overview of the history and cultivation of cannabis, as well as the different strains and compounds used in medicinal cannabis. It also covers the medical benefits of cannabis, such as its use in treating chronic pain, epilepsy, and multiple sclerosis. The article concludes with a discussion of the short-term and long-term effects of cannabis use, as well as the regulatory implications of its use.

RUNNING HEAD: MEDICINAL CANNABIS 1
Medical Cannabis
Student Details:

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Contents
Introduction of Medicinal Cannabis................................................................................................3
Medical Benefits of Cannabis..........................................................................................................4
Glaucoma.....................................................................................................................................5
Asthma.........................................................................................................................................6
Anti-emetic movements...............................................................................................................7
Insomnia and nightmares.............................................................................................................8
Issues rose through the intake of Medicinal Cannabis..................................................................10
Short-term effects of Cannabis intake.......................................................................................10
Long-term effects.......................................................................................................................11
Regulatory implications of Medicinal Cannabis...........................................................................11
Development scheme for the regulation of medicinal cannabis....................................................13
Conclusion.....................................................................................................................................16
Bibliography..................................................................................................................................17

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Introduction of Medicinal Cannabis
Cannabis is known as medication from several thousand years through various cultures.
Cannabis as a medicine has touched a situation of importance within Western medication in the
19th century but developed hindered in disgrace and lawful panels early in the 20th epoch. The
methodical valuation of therapeutic cannabis in human beings is static in initial stages.
Newfangled opportunities in hominid studies have remained unlocked up by the encounter of the
“endocannabinoid system”. “Endocannabinoid system” is quickly increasing information of
“cannabinoid pharmacology”. The agronomy of this herb started from Stone Age and
therapeutic use years back at least 4,000 years which was studied by Mechoulam in 1986. During
1843, scientist and physician named as W.B.O’ Shaughnessy observed an analgesic, anti-emetic,
hypnotic and anti-spasmodic in India. Later, he tested the cannabis resin in ethanolic solutions on
goats, dogs and himself (Patrick, 2013).
Cannabis also known as hemp is one of the “phytochemically” superlative considered
plant classes. The marijuana shrub comprises of more than 100 diverse compounds called
“cannabinoids”. Further, everyone has diverse effect on the human body. The two main
chemicals used in the medicine are “Delta-9-tetrahydrocannbinol (THC) and cannabidiol
(CBD)”. The Cannabis shrub is fast growing, lush which matures in 60 days when grown under
optimum light and heat conditions and after grown in outdoor cultivation for 3-5 months
(Wilkinson, 2003). There are two major Medicinal classes of Cannabis known as sativa and
indica which are basically used for therapeutic and recreational determinations. Saliva’s are
referred for “head-high”, which reduces the anxiety level and stress and help to increase the
focus and imagination. Indica’s are related with whole body belongings like increment in deep

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relaxation and reduction of insomnia (Carter, 2019) . Therefore, the two major scientific terms
for medicinal cannabis are: Cannabis sativa and Cannabis indica. Cannabis is basically used to
treat disorders like desire for food forfeiture, Crohn’s syndrome, epilepsy, mental wellbeing
conditions like schizophrenia and “posttraumatic stress disorder (PTSD)”, Alzheimer’s disease,
cancer, anorexia, nausea, numerous sclerosis, pain, muscle tremors, cachexia (wasting syndrome)
and, glaucoma. Cannabinoids are the vigorous compounds in medicinal cannabis are comparable
to compounds the body creates that are tangled in hunger, effort, pain and remembrance.
Recently, FDA permitted two man-made cannabinoid medications like “dronabinol
(marinol, syndros) and nabilone (cesamet)” for the dealing of spewing and unsettled stomach
from chemotherapy. Common side effects of consuming cannabis are blood shot eyes, increased
heartbeat, low blood pressure, depression, hallucinations and, dizziness. The intake of cannabis
in early ages affects IQ and psychological health functions as cannabis comprises some same
substances which are bring into being in Tobacco. Smoking the cannabis harms the lungs and
increases the threat of Bronchitis, and other lung disorders (Lava, 2018). This report includes the
medicinal uses, significance, purpose and reviews of medicinal cannabis.
Medical Benefits of Cannabis
The moderated necessity for the medicine was improved by the institution of more
consistent medicines alike aspirin for the release of ache in addition to niggles, “chloral and later
barbiturate as hypnotics”, and in conclusion the “benzodiazepines and phenothiazine’s as
tranquillizers”. Furthermore, new-fangled solicitations for the medication in the dealing of
glaucoma, insomnia, nausea and spewing in cancer chemotherapy were established (Ethan B.
Russo, 2014)

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Glaucoma
In 1971, Hepler and Frank observed the reduction of intraocular pressure by smoking the
marijuana leaves after 30-40 minutes by approximately 45%. Later, this outcome was engrained
by other researchers, by consuming the abstract of cannabis or a corresponding amount of THC.
Furthermore, researches reflected that smoking cannabis with 1-2% THC helped to reduce IOP.
20-30mg of THC in cannabis when inhaled reduced both blood pressure and IOP in marijuana
trusting, varied glaucoma. Oral management of cannabis to vigorous matters decreased visual
rigidity with quantities of higher than 20mg THC. Common side effects observed in the patients
through the use of marijuana adolescent was acute pain reaction, tachycardia, paranoia,
depersonalization, and palpitations. Topics with exposed slanting glaucoma did not know-how
any change when THC with 0.5-1.5% was topically smeared in dainty inorganic oil. The effects
continues extensive than that persuaded in pilocarpine which is a conservative eye droplet.
Conversely, the regulator eye likewise practiced a reduction in compression representing
complete immersion of the treatment (Mary Lynn Mathre, 2012).
PG (Prostaglandins) is recognized to be tangled in the preliminary visual hypertensive
stage. Indomethacin in addition to aspirin has been described to entirely wedge this stage by
incompletely constraining IOP with a concentration of 35-50% afterward venous supervision of
water soluble cannabis derivative substantial. Therefore, this recommends that IOP is not reliant
solely on PGs. The possessions of cannabis were recommended in 1976 by Perez-Reyes to be
centrally analgesic (Naftali T, 2014).
Asthma
In 1969 observed by Grinspoon, cannabis was castoff for the dealing of respiratory
asthma. Although lately it was perceived that consumption of cannabis with THC persuaded

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bronchodilatation in fit young men. Researchers also showed that smoking cannabis with
isoproterenol causes a quick alteration of the “bronchospasm and hyperinflation” related to
methacholine and exercise-induced asthma. When THC aerosolized was directed to asthmatic
patients, 3 out of 5 faced an important bronchodilatory consequence. The supplementary two had
unembellished bronchoconstriction related with ribcage uneasiness and bad throat (Morgan,
1997). In usual matters, THC aerosolized triggered bronchoconstriction which was a lesser
amount of than that produced by isoproterenol afterward 5 min then suggestively superior after 1
to 3 hours (Charilaou, 2017). Generally, the bronchial tree and the plane tissues have remained
reappointed to indenture subsequent management of PG (prostaglandin) while PGE’s persuaded
a reduction due to advanced stages of PG’s in the lungs and the strong bronchoconstrictor
consequence. In 1976, Howes and Osgood assumed the reticence of PG-synthesis as a method of
exploit for the cannabinoids. In vitro indication recommends that the physical belongings of
cannabis might be facilitated by PGs. Researchers also presented that smoking cannabis by fit
undertakes formed important increment in precise “airway conductance (AC), FEV (forced
expiratory volume) and HR (heart rate)”. No self-consciousness of the paraphernalia of cannabis
on AC and FEV perceived subsequent PG management but heart rate was pretentious.
Anti-emetic movements
Patients who expected mustine, prednisone, vincristine and procarbazine therapies for
Hodgkin’s disorder resulted in less unsettled stomach and vomiting when they inhaled cannabis
preceding to chemotherapy in early 1970’s. These consequences encouraged the probing of
together THC and cannabis as possible anti-emetic agents for patients who are accepting cancer
chemotherapy. Emesis produced by some medications was more receptive to the effects of THC
than other. In elevation amount of doxorubium, methotrexate, fluorouracil and

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cyclophosphamide combinations retorted to THC. There existed little advantage in a rare patients
getting mustine and “nitrosoureas chemotherapy”. In other judgments where THC was connected
to metoclopramide, and another antiemetic, thiethylperazine, no alteration bring into being
among the antiemetic belongings of these constituents (Machado Rocha, 2008). Numerous
aftereffect were experienced by matters vacillating from psychosomatic ‘high’ to tranquility,
orthostatic hypotension, somnolence, augmented heart rate and, dysphoria. Researchers and
physicians also investigated that patient agonized from depression, nightmares, mental
confusion, blurred vision, visual phantasm, amnesia and, collapsing. However, usage of
Nabilone is not barren of lateral possessions which contain dehydrated mouth, truncated blood
pressure, drowsiness, divided coordination and faintness.
Insomnia and nightmares
Cannabis is beneficial for the promotion of sleep. Researches by Babson and Bonn
Miller, recommended that THC (tetrahydrocannabinol) is the main psychoactive constituent of
Cannabis. However, cannabinoids like CBD (cannabidiol) have “psychoactive and non-
psychoactive properties”. Cannabis is categorized by sub-species of plant which varies
considerably with regards to associated concentration of cannabinoid (Katherine A. Belendiuk,
2015). Cannabis pressures attained in US dispensaries are typically classified as 3 descriptions:
indica, sativa and amalgam (cross-breed of both sativa and indica). For the effective treatment of
nightmares and insomnia, hybrid plant species were sub-divided into principally sativa and
chiefly indica, demonstrating the leading classes for all plant. Cannabis floret deliberations of
CBD and THC were used. Cannabis use disorder (CUD) was identified by means of the
“Structured Clinical Interview-Non-Patient Version for DSM-IV” which was researched by First,
Spitzer, Gibbon and Williams in 1995 (Katherine A. Belendiuk, 2015).

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Cannabis is used for the treatment of some more health conditions like (Railton, 2018):
 Chronic Pain- Chronic pain is a leading reason of disability, which affected more
than 25 million adults in the US. Cannabis contains cannabinoids which acts on
the wits receptors are effective for discharging chronic pain.
 Inebriation and drug obsession- Usage of cannabis help individuals to overcome
the alcohol addiction or opioid reliance.
 Melancholy, post-traumatic pressure syndrome and communal apprehension-
Usage of cannabis might alleviate indications of social anxiety.
 Numerous Sclerosis- the short-term usage of oral cannabinoids improves
indications of spasticity among beings with multiple sclerosis. Although, the
optimistic things have been found to be uncertain.
 Epilepsy- the FDA approved the usage of a medication containing cannabidiol
(CBD) for the handling of erratic and unembellished types of epilepsy which is
recognized as “Lennox-Gastaut syndrome and Dravet syndrome” in June 2018
(Railton, 2018). This kind of CBD-based medicine is referred as Epidiolex. CBD
is not psychoactive; drug is used as a purified form of CBD.

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Issues rose through the intake of Medicinal Cannabis
Cannabis is the most usually consumed illegitimate medication in the United States. It
was observed that in 2015, 11 million young adults used marijuana in the last year.
Short-term effects of Cannabis intake
When an individual smolders cannabis, THC rapidly permits from the lungs into the
blood tributary. The blood transmits the compound to the brain and other structures through the
body. The body engrosses THC gradually when the individual eats or nibbles it.
Source: (NIDA & Drug abuse gov., 2018)
THC acts on precise brain cell receptors which normally respond to regular THC-like
substances. Cannabis over activates shares of the head which contains maximum count of these
receptors. Effects like: transformed wisdoms, altered sense of period, mood change, reduced
body effort, diminished memory, delusions, psychosis, trouble with thinking and problem
resolving (Hazekamp, 2012).

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Long-term effects
High intake of cannabis affects brain development. In teenagers, the medication
prejudices discerning, knowledge purposes and reminiscence and also disturbs the brain building
relations amongst the areas essential for functions. Long-term effects in adolescents affect the IQ
level of the individual. Long-term or substantial doses usage of cannabis is related with long-
lasting bronchitis and an augmented threat of “chronic psychosis-related health” diseases
comprising schizophrenia and alternatives of melancholy, in individuals with a tendency to such
diseases. Vascular circumstances comprising myocardial infarction, stroke, and fleeting ischemic
occurrence have also existed associated with cannabis usage.
Other undesirable adversative effects described with severe usage of cannabis comprise
reduced synchronization and enactment, miserable ideations or inclinations, hyperemesis
syndrome, anxiety, and psychotic symptoms (Ethan B. Russo, 2014). Furthermore, long-lasting
possessions might comprise mood disturbances, cannabis use disease, neurocognitive
impairments, and exacerbation of psychotic disorders, withdrawal syndrome as well as
cardiovascular and respiratory conditions. While using cannabis for medicinal purposes
physicians should evaluate the related risks with the doses.
Supervisory inferences of Medicinal Cannabis
The law of hashish remedy is complicated and particular; ownership, farming, and
delivery of this substance, no matter motive, continue to be unlawful at the centralized level,
whilst conditions that allow therapeutic hashish use have installed person legal guidelines and
regulations at the auction of hashish for medicinal functions. In 2013 U.S. “Department of
Justice memorandum” to all U.S. Lawyers, Assistant Lawyer Overall James M. Cole stated that

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in spite of the performing of nation laws approving cannabis manufacturing and auction having a
controlling shape this is hostage to the same old combined efforts of centralized authorities
functioning collectively with native authorities, prosecution of people humanizing and allocating
cannabis to strikingly sick individuals for therapeutic motive has now not been recognized as a
central precedence (Mary Barna Bridgeman, 2017). There are, however, other controlling
insinuations to keep in attention founded on the centralized perimeter of cannabis. Doctors
cannot legally “prescribe” therapeutic hashish medication, given its Schedule I class, however as
a supernumerary rendering with republic edicts may furthermore confirm or sanction victims for
dealing.
Medicinal cannabis fees aren't reimbursable complete management medicinal help
packages or non-public fitness underwriters. The incomplete obtainability of medicinal research
to provision or disprove curative rights and suggestions for practice of hashish for therapeutic
determinations has recurrently absent both monarchy lawmaking management and physicians to
be contingent on “anecdotal proof”, which has no longer been exposed to the indistinguishable
severities of peer valuation and inspection as properly-performed, “randomized hearings”, to
authenticate the care and efficiency of therapeutic hashish medicine. Furthermore, though charm
single-entity medicinal medicines, together with dronabinol, were inaccessible, estimated, and
putative to be used from side to side the FDA; a shrub cannot be untested and form shaped
through a commercial person (FDA, 2019). In spite of this interference, some groups, along with
GW Drugs, are mass causing hashish plants and removing complex combinations or unattached
cannabinoids for medicinal hearings. The multifaceted pharmacology related with the frequent
affluences and communications between substances in the hashish plant attached with

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conservational variables in agronomy further obfuscate law, calibration, spotlessness, and
competence as a botanic medication creation.
Development scheme for the regulation of medicinal cannabis
In UK, drugs professed by strategy creators to have no medicinal value and in elevation
danger of misappropriation are positioned in Schedule 1 of the “Misuse of Drugs Regulation
2001”. These medications cannot be recommended, and inquiries can only be accompanied
under a “Home Office License”. In UK, unrestricted cannabis centered merchandises were
moved to from Schedule 1 from Schedule 2 on 1, November 2018 (Tom P Freeman, 2019). Non-
medicinal artificial cannabinoids were not rearranged and persisted in Schedule 1. CBD has
negligible danger of misapplication and was never arranged in the UK.
In the US, cannabis obtainable for therapeutic use in 33 states and for non-medicinal use
in 10 states. Though, both endure illegitimate further down federal law. Additional latest
progresses include the legislature of cannabis for non-medical use in Canada. The WHO (World
Health Organization) has suggested that cannabis must be rearranged within international law
due to mounting indication of its therapeutic applications. In UK, cannabis created produces in
Schedule 1 can be approved by physicians on the “General Council Specialist Register”. At
present, general physicians cannot recommend them in UK. These merchandises are not
approved for exact medical suggestions however, are used off license for therapeutic
determinations in multiple nations, and are specialized for superiority permitting to good
industrial services. Examples comprise herbal cannabis (flowery substantial from the cannabis
shrub). The recommended direction of management is over and done with a medicinal nebulizer
device and smoldering is presently banned under NHS regulation. For oral management abstracts

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form the cannabis plants are also obtainable. Few cannabis formed merchandises were already
offered for medicine usage before rescheduling in 2018 (FDA, 2019).
Above the historical span, investigators have perceived a mounting attention in the
expansion of treatments and additional purchaser produce resulting from Cannabis and its
composites, which fundamentally embraces CBD (cannabidiol). FDA has recognized the
possible opportunities concerning cannabis and cannabis derived products might compromise
and recognizes the significance interest in the potentials. The organization is dedicated to
safeguard the public health meanwhile also pledges laws to recover the efficacy of controlling
paths for the legalized advertising of suitable “cannabis and cannabis-derived products”.
However, FDA has accepted Epidiolex which typically comprises a disinfected form of the
medicine mixtures CBD for the remedial of annexations related with “Lennox-Gastaut syndrome
or Dravet syndrome” for 2 years old patients. The organization also has accepted “Marinol and
Syndros” for the management in the United States, comprising the dealing of anorexia related
with mass beating in AIDS long-suffering. Syndros and Marinol embrace the active component
dronabinol which is an artificial “delta-9-tetrahydrocannabinol (THC)” which is well-thought-
out the psychoactive constituent of cannabis. Additional FDA accepted medication is Cesamet
which comprises the vigorous constituent nabilone, which has a biochemical structure
comparable to THC and is artificially extracted.
In December 2018, FDA has accomplished its assessment of three “general recognized as
safe” GRAS notifies for the subsequent hemp seed derivative food constituents: “hulled hemp
seed, hemp seed protein powder, and hemp seed oil”. These merchandises can be legitimately

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advertised in human nourishments for the customs pronounced in the announcements, on
condition that they meet the terms with all other necessities.

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Conclusion
From this report concluded about the therapeutic usage of Cannabis, highlighted the uses,
significance, and analyzed the purpose of consumption of medicinal Cannabis (Marijuana).
Research shows that people use cannabis to bring about sleep issues. People who testified by
means of catnap medicines at lower occurrence castoff cannabis with advanced meditations of
THC. THC deliberations have reflected to have thought-provoking outcome that can lead to
deprived sleep. A person who uses cannabis for the reduction of nightmares uses classes of
cannabis (i.e., sativa) which is related with minimized threat of CUD. The most significant
upcoming way is to test possible third variables, comprising PTSD and “co-occurring substance
use”. Extra investigational is required to clarify the consequence of cannabis classes and
"cannabinoid meditation (THC and CBD) on the protection and efficiency of cannabis for the
administration of sleeping issues. Lawmaking leading usage of medicinal cannabis endures to
change promptly, requiring that druggists and further clinicians keep well-informed of new or
altering state guidelines and recognized inferences. Eventually, as the medicinal cannabis
background endures to change, infirmaries, acute care amenities, clinics hospitals, and long-term
care interiors need to contemplate the repercussions, address logistical anxieties, and explore the
viability of authorizing long-suffering admission to this management.

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Bibliography
Carter, A. (2019, 04 8). Sativa vs. Indica: What to Expect Across Cannabis Types and Strains.
Retrieved from Healthline: https://www.healthline.com/health/sativa-vs-indica
Charilaou, P. A. (2017). Trends of cannabis use disorder in the inpatient: 2002 to 2011. The
American journal of medicine, 130(6), 678-687.
Ethan B. Russo, F. G. (2014). The Handbook of Cannabis Therapeutics: From Bench to Bedside.
Routledge: The Haworth Press.
FDA. (2019, 02 04). FDA Regulation of Cannabis and Cannabis-Derived Products: Questions
and Answers. Retrieved from FDA Govt: https://www.fda.gov/news-events/public-
health-focus/fda-regulation-cannabis-and-cannabis-derived-products-questions-and-
answers
Hazekamp, A. &. (2012). Cannabis‐from cultivar to chemovar. Drug testing and analysis, 4(7-
8), 660-667.
Katherine A. Belendiuk, K. A. (2015). Cannabis species and cannabinoid concentration
preference among sleep-diturbed medicinal cannabis users. Addictive Behaviors, 50, 178-
181.
Lava, N. (2018, 12 15). Medical Marijuana FAQ. Retrieved from WebMD:
https://www.webmd.com/a-to-z-guides/medical-marijuana-faq
Machado Rocha, F. C. (2008). Therapeutic use of Cannabis sativa on chemotherapy‐induced
nausea and vomiting among cancer patients: systematic review and meta‐analysis.
European journal of cancer care, 17(5), 431-443.
Mary Barna Bridgeman, D. T. (2017). Medicinal Cannabis: History, Pharmacology, And
Implications for the Acute Care Setting. US National Library of Medicine, 42(3), 180-
188.
Mary Lynn Mathre, R. N. (2012). Cannabis in medical practice: a legal, historical and
pharmacological overview of the therapeutic use of marijuana. USA: MC Farland.
Morgan, D. R. (1997). Therapeutic uses of cannabis. Amsterdam: CRC press.
Naftali T, M. R. (2014). Cannabis for Inflammatory Bowel Disease. Digestive Diseases, 32(4),
468-474.

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NIDA, & Drug abuse gov. (2018). What is marijuana? Retrieved from National Institute of Drug
Abuse: https://www.drugabuse.gov/publications/drugfacts/marijuana
Patrick, G. L. (2013). An Introduction to Medicinal Chemistry. Oxford: Oxford University Press.
Railton, D. (2018, 08 02). Marijuana: Good or bad? Retrieved from Medical News Story:
https://www.medicalnewstoday.com/articles/320984.php
Tom P Freeman, C. H. (2019). Medicinal use of cannabis based products and cannabinoids. The
BMJ, 365(1), 1141.
Wilkinson, J. D. (2003). Medicinal cannabis: is Δ9–tetrahydrocannabinol necessary for all its
effects? Journal of Pharmacy and Pharmacology, 55(12), 1687-1694.