Metabolic syndrome Pharmacology Report 2022

Pharmacology Report
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Abstract:
Metabolic syndrome is the co-morbid condition of various diseases such as hypertension,
impaired glucose tolerance, dyslipidaemia and obesity. This complex disease can be
modelled in high fat diet induced obesity model. Metabolic syndrome was developed in
Sprague-Dawley rats through feeding high fat diet for 10 weeks. Efficacy of drug X (100
mg/kkg) was evaluated by conducting study comprising of three groups such as normal
control, disease control and treatment control. Drug X was administered to treatment control
group for the duration of 4 weeks. At the end of 4 weeks; serum was collected to estimate
glucose, insulin, cholesterol, and triglycerides. Drug X significantly reduced all the evaluated
biochemical parameters. High fat diet induced rodent models are useful for the induction of
metabolic syndrome and evaluation of drugs for the treatment of metabolic syndrome.
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Table of Contents
Introduction.........................................................4
Methods..............................................................4
Results...............................................................5
Discussion............................................................6
References............................................................8
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