Molecular Basis of Ageing | Report

Runninghead: MOLECULAR BASIS OF AGEING
MOLECULAR BASIS OF AGEING
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MOLECULAR BASIS OF AGEING
Abstract
The ageing is a natural phenomenon of an individual to grow older with time. Ageing is
related to degrading physiological and psychological activity. There are several theories
related to the ageing process. The theories are based on the molecular mechanism of the cell,
genetic interaction, signalling pathway and epigenetic mechanisms. Many factors of the
regular molecular mechanism are found to be related to the ageing process. The study will
shed light on the different theories of ageing stressing on the continuity theory, biological
basis, genetic instability and the mitochondrial instability. The link between two major
factors of ageing will also be discussed in the dissertation. The study will give a vivid idea of
therapeutic approaches to prevent ageing or enhancing a healthy life.
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MOLECULAR BASIS OF AGEING
Introduction:
Ageing is a biological process via which the physical, psychological and
physiological functional efficiency decreases, causing a loss of decline in survival and
fertility rates. The physical symptom of ageing can be visualized. Some symptoms of ageing
are visible fine lines, wrinkles, pores, blotchiness, age spots, uneven skin tone, rough and dry
skin. The average lifespan of human being was less in previous days, and the root cause was
infections, diseases. The development and improvement of antibiotics, vaccines and hygiene
knowledge, hygiene system laid down the rate of mortality, increasing the average life span
of the population. In 1990, three diseases pneumonia, diarrhoea and tuberculosis played the
chief cause of death, contributing one-third of the total death rate. Almost 30.4% of the died
individuals were children, aged below five years. After a few years, in the year of 1997, the
child death rate by those diseases dropped down to 1.4 % (cdc.gov, 2020).
The dissertation will focus on the different theories and molecular basis of ageing to
analyze, evaluate and develop therapeutic approaches to decrease the mortality rate and
increase the lifespan of the population. The external and internal theories of ageing will be
discussed vividly in the dissertation, stressing on the potential advancement of medical
practices based on the understanding of those theories. This dissertation will also shed light
on the relation between natural selection and reproductive age.
Discussion:
The continuity theory:
The theory is based on the continuity of maintaining the lifestyle of older people.
Older people adapt and change the strategies of lifestyle, which are connected to their past
experiences. The theory is based on the psychology of an individual. The other theories based
on psychology are disengagement theory and activity theory (Stjernborg, Wretstrand and
Tesfahuney 2015).
The Biological Basis of ageing:
The biological basis theory relates to the progressive declination of physiological
health with diseases and disabilities. The approach of treatment based on the biological basis
is focused on research and development of the pathways that slows down with the ageing
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