MRI In Breast Cancer Screening Rapid Review Case Study 2022

Running head: MRI IN BREAST CANCER SCREENING RAPID REVIEW 1
MRI In Breast Cancer Screening Rapid Review
Ishtiaq Karim
Student Id: 5024122

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Is MRI Imaging Effective In Early Diagnosis of Breast Cancer among Young Women?
A Rapid Review of Evidence
Executive Summary
Background
There are high prevalence and incidence of breast cancer amongst females, primarily
amongst females with breast carcinoma history in their families or females who have endured
chest radiation therapies prior to 30 years of age, or with predisposing genetic mutations like
BRCA1/2. These groups of women show high likelihood (20-65 percent) of breast
malignancy development relative to general population (11 percent). The main aim of this
study is to undertake rapid systematic review of literature to establish the effectiveness of
breast MRI in breast cancer diagnosis amongst young women.
Objective
To carry out a rapid review study and recapitulate most recent and suitable evidence
from systematic review alongside meta-analysis or a combination of the two designs
published between 2009 and 2019 to comprehend the breast MRI effectiveness in early breast
cancer diagnosis amongst high-risk females with particular focus on determining whether
breast MRI can assist enhance likelihood of detecting breast cancer amongst this population.
Criteria for considering studies
Any meta-analysis and systematic reviews with breast MRI screening for breast cancer stood
included. The studies were restricted to English and period between 2009 and 2019.
Types of Participants
Young women with breast carcinoma history in their families or females who have
experienced chest radiation therapies prior to 30 years of age, or with predisposing genetic

MRI IN BREAST CANCER SCREENING RAPID REVIEW 3
mutations like BRCA1/2. These groups of women show high likelihood (20-65 percent) of
breast malignancy development relative to general population (11 percent).
Types of intervention
Any meta-analysis and systematic reviews which evaluated the effectiveness of breast
MRI in breast diagnosis cancer amongst young females.
Types of Studies
Any meta-analysis and systematic reviews which assess the MRI effectiveness in screening
breast cancer amongst young women.
Outcomes
The primary outcomes stood effectiveness of breast MRI on screening of breast cancer.
Search Strategy
The search strategy was performed on five databases including MEDLINE, PubMed,
Cochrane, EMBASE and CINAHL. The best existing evidences stood acknowledged
considering the PICO elements. The exclusion and inclusion criteria stood taken into account
for reviews’ selection.
Methodological Quality
Seven articles chosen were appraised for the reliability of methodology prior to inclusion in
the final review utilizing AMSTAR as a reliable and effective instrument utilized in assessing
meta-analysis and systematic reviews methodological quality. AMSTAR contains eleven
criteria with scores ranging from zero to eleven (0-lowest; 11-highest).
Data extraction and Data Synthesis
The extraction tool was used to extract data. The info gathered included author, population of
study, year of publication, design of study, searched databases, interventions, quality score as

MRI IN BREAST CANCER SCREENING RAPID REVIEW 4
well as outcome measures. The findings and results of revues were also presented in narrative
form and encompasses figures and facts alongside tables to help in desired presentation.
Results
After reviewing and analyzing the seven reviews included, it was discovered that breast MRI
is highly sensitivity to detect breast cancer and must always be used in conjunction with
mammography to boost detection potentials.
Conclusion
From the gathered evidence, it is concluded that breast MRI is an effective screening and
diagnosing technique for breast cancer amongst young women.
Keywords
Keywords: MRI in cancer screening, systematic reviews, breast cancer, MRI imaging, Breast
ailments and detecting breast carcinoma

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Table of Contents
Executive Summary...................................................................................................................2
Background.............................................................................................................................2
Objective.................................................................................................................................2
Criteria for considering studies..............................................................................................2
Types of Participants..............................................................................................................2
Types of intervention..............................................................................................................3
Types of Studies.....................................................................................................................3
Outcomes................................................................................................................................3
Search Strategy.......................................................................................................................3
Methodological Quality..........................................................................................................3
Data extraction and Data Synthesis........................................................................................3
Results....................................................................................................................................4
Conclusion..............................................................................................................................4
Keywords................................................................................................................................4
1. Background............................................................................................................................8
2. Objectives...............................................................................................................................9
3. Criteria for Considering Studies...........................................................................................10
3.1 Types of Studies.............................................................................................................10
3.2. Types of Participants.....................................................................................................10
3.3. Types of Interventions...................................................................................................10

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3.4. Types of Outcomes........................................................................................................11
4. Search Strategy.....................................................................................................................11
5. Methods of Review..............................................................................................................12
5.1 Assessment of methodological quality...........................................................................12
5.2 Data Extraction...............................................................................................................12
5.3. Data Synthesis...............................................................................................................13
6. Results..................................................................................................................................13
6.1. Description of Search Results.......................................................................................13
Figurer: PRISMA Flow diagram for search strategy...........................................................14
6.2. Description of Included Reviews..................................................................................14
8. Discussion............................................................................................................................18
8.1. Summary of Findings....................................................................................................18
MRI Effectiveness............................................................................................................18
MRI in Breast Cancer Screening Amongst Young Women.............................................20
8.2. Quality of Evidence.......................................................................................................23
8.3. Potential Biases in Review Process...............................................................................23
9. Conclusion............................................................................................................................24
9.1. Implication for Practitioners..........................................................................................24
9.2 Implication for Researchers............................................................................................24
References................................................................................................................................25
Appendices...............................................................................................................................28
Appendix A: PRISMA Flow Diagram.................................................................................28
Appendix B: Search Strategy for PubMed...........................................................................29

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Appendix C: Data extraction Form......................................................................................30
Appendix D: AMSTAR 2 Critical Appraisal Form.............................................................32
Appendix E: Time Frame.....................................................................................................37

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1. Background
The most prevalent malignancy occurring among the women is Breast cancer. Women
with the strong history of breast carcinomas in their family or women, who have undergone
any kind of chest radiation therapy before 30 years of age, or have the predisposing genetic
mutation (e.g., BRCA1 or BRCA2 mutation) (20% to 65%) possess a higher chance of
developing breast malignancy in comparison to general population (11%) (Wang, 2017). The
effective diagnosis of breast cancer at the early stage can significantly help in reducing the
breast cancer related mortality and morbidities.
Most of the techniques used for the screening of breast carcinomas have some
limitations, such as some are expensive, prolonged and not suitable for younger women
(Roganovic et al, 2015). Magnetic resonance imaging is being considered as the most
effective screening modality for early detection of breast lesions. Therefore, this study will
conduct a critical review of the existing evidences from the literature in order to understand
the effectiveness of MRI Imaging in early diagnosis of breast cancer in women with high-risk
of cancer.
The purpose of this research is to inspect and analyse the effectiveness of MRI breast
for the early diagnosis of breast cancer among the women, who are at the higher risk. The
main objective is to understand the significance of early diagnosis of the breast cancer, as the
prevalence and incidences of breast cancer is significantly increasing among young women.
Memon et al (2015) have informed that the exposure to radiations and family history of
breast cancer can result in increasing the risk of the cancer among young women and a
delayed diagnosis of the disease can increase the mortality rates (Paluch-Shimon et al, 2016).
Therefore, there is a substantial need of appropriate and effective screening tools for the early
detection of the breast cancer among young women.