MRSA Disease: Symptoms, Pathogenicity, Diagnosis, Treatment and Prevention

MRSA is a contagious infection caused by Staphylococcus bacteria. Learn about its symptoms, pathogenicity, diagnosis, treatment and prevention. Understand the means of transmission, incubation time, and epidemiology of MRSA. Get insights into the diagnosis, treatment and prevention of MRSA.

Running head: MRSA DISEASE 1
Microbiology
Name
Institution
Professor
Course
Date

2
MRSA DISEASE
MRSA DISEASE
For my unknown ID performance assessment task, I picked agar plate number 17. In the
process of identifying which bacteria I had, the first technique I performed was to make a streak
plate using the bacteria from my agar plate. Next, I heated and fixed the bacteria to a slide in
order to perform other identification tests on it. One of the first differential tests run on a
bacterial specimen in any laboratory to determine identification and drug therapy is the gram
stain; therefore, this was the next test I performed on my bacteria.
The results of the gram stain revealed the bacteria were gram-positive since it retained the
deep purple colour (if the bacteria on the slide were pinkish red, then it would have been gram
negative) and the morphology was cocci because of the round shape of the bacteria. Since the
bacteria were gram-positive and not gram-negative, this allowed me to exclude the following
bacteria: Pseudomonas aeruginosa, Klebesiella pneumonaie, and Proteus vulgaris because they
are all gram-negative.
In addition, I was able to exclude the following bacteria: Bacillus cereas, Mycobacterium
smegmatis and Listeria monocytogenes based on the fact that they are gram-positive rods and my
bacteria was a gram-positive coccus. This brought me to the next identification test which was
the catalase test. My bacterium was catalase positive because the catalase test produced bubbles
if there would have been no bubbles present, then the results would have been catalase negative.
The results of the catalase test allowed me to exclude the bacteria Streptococcus
pyogenesis which is gram-positive cocci and catalase negative. In conclusion, based on the
results of my tests which were gram-positive, cocci, and catalase positive; I determined that my

3
MRSA DISEASE
agar plate number 17 bacteria was Staphylococcus aureus a causal bacterium responsible for
MRSA (Methicillin-resistant Staphylococcus aureus) disease.
General Description of MRSA Disease
MRSA is a contagious infection caused by Staphylococcus bacteria. The disease is highly
resistant to antibiotics making its treatment challenging. By nature, the bacteria do exist in the
nose and on the skin, but little do they cause harm (Shrestha, Fraser & Gordon, 2017). However,
when the bacteria start to multiply uncontrollably, they lead to an MRSA infection.
Means of Transmission of MRSA
The disease can be transferred by agents that include sharing of items with someone who
has MRSA such as clothes, sheets and towels. In addition, touching someone who has it or
surfaces that have MRSA in them also lead to disease transmission (Shrestha, Fraser & Gordon,
2017). Also, the disease can be transferred easily to people with open wounds, those who use
feeding tubes in hospitals and those with burns.
The Incubation Time of MRSA
Since an MRSA is a staph disease, there should be some already existing bacteria and
mucous membranes within the individuals’ body. Therefore, it is difficult to determine the exact
and correct period of incubation for the disease. But, if the infections are inherited from another
person through open wounds or damaged mucous membranes, the period of incubation ranges
from the first day to the tenth day (Lee, Pettitt & Dancer, 2018).

4
MRSA DISEASE
MRSA Symptoms.
The disease does not dispose any serious symptoms to anyone having it unless a
screening test is conducted for the disease. However, if the MRSA disease prolongs and gets
deeper into the body, reddening of the skin, swelling, pus formation and pain are among the
characteristics that the patients start to experience (Shrestha, Fraser & Gordon, 2017). Again, if
the condition persists in the body, dizziness, aching, confusion and chills are experienced by the
patient.
Pathogenicity of the Bacteria
1. Structural defences against phagocytosis.
The DNA of the bacteria is integrated from the dead genome hence the bacteria can
undergo mutations all the time for survival. The gene can be altered by a single nucleotide
granting resistance to the microorganism (Kon & Rai, n.d.). Consequently, they exist naturally in
numerous numbers to increase the chances of survival from being digested by the white blood
cells. Lastly, the outside layer of their cells is bilayer that reduces the rate at which phagocytosis
takes place.
2. Enzymes
Enzymes within the body are inhibited by the bacteria. This mechanism uses different means of
modifying the antibacterial structural compounds (Kon & Rai, n.d.). Hydrolysis is done on the
enzymes together with the capability to modify penicillin-binding proteins (PBP) within the host.

5
MRSA DISEASE
3. Toxins
The bacteria produce efflux pumps which becomes a complex defense mechanism as it is
also supported by the outer membrane. This limits the chances of toxin penetration into the
bacteria hence creating room for more replications and dominance (Kon & Rai, n.d.).
4. Resistance to antibiotics
The membrane outside the Gram-negative bacteria on the outer part of the cell wall
contains lipids that are bilayer. This minimizes passage of hydrophilic compounds from the
antibiotics (Kon & Rai, n.d.). Other factors that limit the passage of drug to the bacteria are its
size and different shapes in which it exists.
Epidemiology of MRSA
i. Incidence
According to the analysis done by Shrestha, Fraser and Gordon (2017), the incidence of
MRSA ranges from ten to thirty per 100000 person-years. Also, the rate of increase is directly
proportional to time such that as the time goes, the patient record is increasing as reported by the
Centre for Disease Control ("Methicillin-resistant Staphylococcus aureus (MRSA) Infections |
MRSA | CDC", 2018). Also, age is a major determinant of the MRSA infections with high rates
in the first year of life, low incidences in adults that are young and a gradual rise for the old
individuals together with diabetic people being prone to risks of MRSA infections (Lee, Pettitt &
Dancer, 2018).

6
MRSA DISEASE
ii. Mortality
Under a study conducted by Shrestha, Fraser and Gordon (2017) in Canada, higher death
rates of the disease were those above sixty-five years old with minimal recordings from younger
ages. This was followed by 1104 cases of deaths containing diabetic and AIDS in blacks, males
and females.
iii. Morbidity
High prevalence of MRSA occurs in diabetic people and people living with AIDS.
Moreover, MRSA affects body parts with a high prevalence on buttocks, armpits and even eyes.
Lastly, Lee, Pettitt and Dancer (2018) illustrates that high morbidity rates are contributed by
people with burns.
Diagnosis, Treatment and Prevention of MRSA
The disease can be diagnosed by a doctor by doing a check on a nasal secretion of
the bacteria, or a check can be done on a tissue sample (Lee, Pettitt & Dancer, 2018). The
sample to be tested is taken to the laboratory and placed where bacterial growth can be enhanced
using an appropriate dish of nutrients for 48 hours.
Moreover, after the test has been conducted and MRSA has been found, one is
subjected to decolonization which entails; use of antibacterial cream that is applied on the
nose three times a day, five day washing of the infected area by antibacterial shampoo and
changing of towels, beddings and clothes with the laundry being washed at high
temperatures away from people (Kon & Rai, n.d.) .

7
MRSA DISEASE
When the person is infected, the patient is subjected under antibiotic treatment that works
against the MRSA. This may include injections or tablets that may take some days to few
weeks’ completion time. In order to avoid the spread of the disease, the person may be
required to stay in a personal room or with others who also have MRSA.
MRSA can be prevented in different ways despite the area the patient resides either
at the hospital or home. To begin, proper hand washing before and after eating should be
observed to avoid the spread (Lee, Pettitt & Dancer, 2018) . In addition, instructions given
regarding taking care of devices that may lead to infection such as urinary catheters and
wound caring should be considered. Lastly, reporting of any unclean facilities in hospitals
should be done to people with authority in hospitals without fear.
In conclusion, if all prevention, treatment and control measures are taken care of,
there will be low incidence rates and morbidity rates of MRSA in different areas. It should
also be clear that prevention is better than cure.

8
MRSA DISEASE
References
Kon, K., & Rai, M. Antibiotic resistance.
Lee, X., Pettitt, A., & Dancer, S. (2018). Quantifying the relative effect of environmental
contamination on surgical ward MRSA incidence: An exploratory analysis. Infection,
Disease & Health, 23(3), 127-136. doi: 10.1016/j.idh.2018.02.005
Methicillin-resistant Staphylococcus aureus (MRSA) Infections | MRSA | CDC. (2018).
Retrieved from https://www.cdc.gov/mrsa/
Shrestha, N., Fraser, T., & Gordon, S. (2017). Patients Colonized with Methicillin-Susceptible
Staphylococcus aureus Rarely Get Methicillin-Resistant Staphylococcus aureus
Infections. Open Forum Infectious Diseases, 4(suppl_1), S638-S639. doi:
10.1093/ofid/ofx163.1695