(Berry & Atta, 2016). There is no known definitive occurrence triggering PE, it is
regarded as a disease of theories. Currently, insufficient knowledge has often
linked genetic mechanisms, immunological factors and inflammatory responses
as associated with its occurrence. Interaction of gene and the environment often
occurs among familial linage (Lin et al., 2015).
The development of cytokinesis linked to immunological aspects that occur
among candidates who development pre-eclampsia linked to the development
of transforming growth factor-beta
(TGF-β1)( Crome et al., 2010).
(TGF-β1) is a
multi-functional cytokine that has an impact of altering the balance between the
invasive cytotro-phobias and syncytiotrophoblast which is dependent upon by
the normal pregnancy development contributing to the regulation of maternal
immunity state against fetal allograft.
Polymorphisms rs1800468 and rs1800469 are found in the promoter region of
the
TGF-β1 gene and are tasked with the regulation of protein expression levels
which are capable of triggering alterations in the sites of splicing due to the
inherent exchange of the two variant bases in the gene transcription states. The
availability of the polymorphic allele A of the rs1800468 polymorphisms
intercepts the binding effect of the protein in the Camp Response Element – CRE
in the nuclear transcription factor leading to the production of the
TGF-β1 in the
circulation system. Further rs1800469 polymorphism has been linked to
increased transcriptional activity increasing the levels of
TGF-β1 (Chang et al.,
2016).
Because of this, the
TGF-β1 offers an exertion on the physiological and path
physiological processes linked to fetal development, suppression of the immune
and occurrence of hypertension levels. in this sense, it is fascinating to assess
the contribution of the gene polymorphisms and the overall occurrence of pre-
eclampsia among women (Kajdaniuk et al., 2011). Thus in attaining this
objective, this task assesses the overall contribution of the polymorphisms
rs1800469 and rs1800468 of the
TGF-β1gene and the development of pre-
eclampsia in its associative risk factors forms.
b.Project Aim(s)
This study aims to assess the effect of polymorphisms rs1800469 and
rs1800468 on the TGF-β1 gene and risk factors linked to pre-eclampsia among
women.
Hypothesis

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TGF-1 polymorphisms among women with pre-eclampsia diagnosis

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