This critical appraisal analyzes the study by Zhang, J.-r.et al., 2015 on the efficacy of Clopidogrel and clinical outcome when Clopidogrel is coadministered with Atorvastatin and Lansoprazole. The study was a randomized control trial that aimed to determine the effectiveness of using clopidogrel in clinical outcomes when it is administered with Atorvastatin and Lansoprazole. The study concluded that there is no major difference in outcome effect when clopidogrel is coadministered with atorvastatin or lansoprazole. The article discusses the strengths and limitations of the study and its applicability to other studies.