The Prevention of Neonatal Respiratory Diseases in the Nicu

Literature Evaluation Table
Student Name:
Change Topic (2-3 sentences):
Criteria Article 1 Article 2 Article 3 Article 4
Author, Journal
(Peer-Reviewed), and
Permalink or
Working Link to
Access Article
Bollani, L., Baraldi, E.,
Chirico, G., Dotta, A., Lanari,
M., Del Vecchio, A., ... &
Orfeo, L. (2015). Revised
recommendations concerning
palivizumab prophylaxis for
respiratory syncytial virus
(RSV). Italian journal of
pediatrics, 41(1), 97.
Yuan, X., Qian, S. Y., Li,
Z., & Zhang, Z. Z. (2016).
Effect of zinc
supplementation on infants
with severe pneumonia.
World Journal of
Pediatrics, 12(2), 166-169.
Abdelbasset, W. K. M.,
& Elnegamy, T. E. H.
(2015). Effect of chest
physical therapy on
pediatrics hospitalized
with pneumonia.
International Journal of
Health and
Rehabilitation Science,
4(4), 219-226.
Azab, S. F., Sherbiny, H.
S., Saleh, S. H., Elsaeed,
W. F., Elshafiey, M. M.,
Siam, A. G., ... & Ismail,
S. M. (2015). Reducing
ventilator-associated
pneumonia in neonatal
intensive care unit using
“VAP prevention
Bundle”: a cohort study.
BMC infectious diseases,
15(1), 314.
Article Title and
Year Published
Revised recommendations
concerning palivizumab
prophylaxis for respiratory
syncytial virus (RSV) (2015)
Effect of zinc
supplementation on infants
with severe
Pneumonia. (2016)
Effect of Chest Physical
Therapy on Pediatrics
Hospitalized With
Pneumonia. (2015)
Reducing ventilator-
associated pneumonia in
neonatal intensive care
unit using “VAP
prevention Bundle”: a
cohort study. (2015)
Research Questions
(Qualitative)/Hypoth
esis (Quantitative),
and Purposes/Aim of
Study
Revise the recommendations
regarding the implementation
of palivizumab in the
deterrence of RSV infection.
To study the effect of
serum zinc in infants with
severe
Pneumonia.
To measure the impact in
pediatrics hospitalized
with pneumonia of chest
physiotherapy.
Evaluating the efficiency
of “VAP prevention
bundle” in reducing VAP
rate in (NICU).
Design (Type of
Quantitative, or Type
of Qualitative)
Qualitative study Quantitative Quantitative Quantitative
Setting/Sample Infants 96 infants diagnosed with
severe
pneumonia
50 children aged
between 29 days to 5
years diagnosed with
severe
pneumonia
NICU of Children
Hospital of Zagazig
University/Neonates with
mechanical ventilation
for ≥ 48 h.
Methods:
Intervention/Instrum
ents
Palivizumab Serum zinc Chest physiotherapy VAP prevention bundle
© 2015. Grand Canyon University. All Rights Reserved.

Analysis RSV is the most common
reason of respiratory
inflammation in children
under 2 years old, and
bronchiolitis is the primary
cause of hospital admission
during the first year of birth,
with hospital admission
highest at age 2. A
multicenter, selective, double-
blind, regulated, clinical study
has proven the safety and
effective potential of
palivizumab.
SPSS18.0 statistical
software, Kolmogorov-
Smirnov
Method, Shapiro-Wilk
method, Chisquare test
have been used to analyse
the test results.
Stata
Version 8.0 program, χ2
Test, unpaired t test have
been used to analyse the
test results.
SPSS statistical software
version 16, Chi-square
test and student t-test
have been used to
analyse the test results.
Key Findings Studies show that 30%-40% of
infants previously admitted
due to bronchiolitis struggle
with asthma and also use anti-
asthma medicines. Studies
show that when palivizumab
was provided to healthy
babies, the number of days
with bronchospasm during the
first year of childhood did
decrease by 61 percent, thus
promoting the theory of direct
damage done by the virus.
The normalization of Zinc
levels with Zinc
Supplements could not
enhance the clinical results
of infants who were
admitted due to
pneumonia. Zinc deficit is
normal in children with
moderate to
severe pneumonia.
Physical chest exercise
showed several number
of improvements in
the pneumonia
hospitalized pediatrics.
The multifaceted
infection and prevention
of the VAP kit decreased
the risk of VAP and the
stay period in NICU.
Recommendations Strict compliance to infection-
control procedures is critical
for reducing the spreading of
RSV and may be affective in
the prevention of pulmonary
virus epidemics.
For infants with a zinc
deficit, zinc treatment can
improve the serum zinc
level to average.
In the treatment
of children who
are hospitalized with
pneumonia, the
paper suggests the
introduction of the chest
physiotherapy program.
VAP prevention bundle
is a combination of
several strategies and it
has been recommended
to other NICU’s.
Explanation of How
the Article Supports
EBP/Capstone
Project
The following article will
reflect upon the Capstone
project as the project is related
to respiratory disorder.
The following article will
reflect upon the Capstone
project as the project is
related to pneumonia.
The following article
will reflect upon the
Capstone project as the
project is related to
pneumonia.
The following article will
reflect upon the Capstone
project as the project is
related to pneumonia.
Criteria Article 5 Article 6 Article 7 Article 8
Author, Journal
(Peer-Reviewed),
and
Permalink or
Working Link to
Access Article
Mannan, M. A., Nahar, N.,
Ahmed, F., Jahan, I., Mosleh,
T., Khan, K. A., ... &
Shahidullah, M. (2018).
Neonatal Pneumonia in NICU
of a Tertiary Care Center.
Bangladesh Journal of Child
Health, 42(3), 112-117.
Yang, Z., Xiao, X., Huang,
Y., He, X., Lu, Q., Chen, S.,
& Lin, Z. (2017). Effects
and mechanisms of
ambroxol inhalation
(Mucosolvan®) in the
treatment of neonatal
pneumonia. Die Pharmazie-
An International Journal of
Li, B., Han, S., Liu, F.,
Kang, L., & Xv, C.
(2017). Budesonide
nebulization in the
treatment of neonatal
ventilator associated
pneumonia. Pakistan
journal of medical
sciences, 33(4), 997.
Min, L. U., & Tan, J.
(2017). Clinical efficacy
of ambroxol combined
with budesonide aerosol
inhalation in treating
neonatal pneumonia.
Chinese Journal of
Biochemical
Pharmaceutics, 37(3),
© 2017. Grand Canyon University. All Rights Reserved.

Pharmaceutical Sciences,
72(10), 604-607.
237-239.
Article Title and
Year Published
Neonatal Pneumonia in NICU
of a Tertiary Care Center (2018)
Effects and mechanisms of
ambroxol inhalation
(Mucosolvan®) in the
treatment of neonatal
pneumonia. (2017)
Budesonide Nebulization
in the Treatment of
Neonatal Ventilator
Associated Pneumonia.
(2017)
Clinical efficacy of
ambroxol combined with
budesonide aerosol
inhalation in treating
neonatal pneumonia.
(2017)
Research
Questions
(Qualitative)/Hyp
othesis
(Quantitative),
and Purposes/Aim
of Study
To study the pneumonia
occurrence and outcomes in
neonatal intensive care unit
admitted sick newborns.
This research aimed
primarily at the diagnosis
and possible causes of
neonatal pneumonia by the
use of ambroxol inhalation
(Mucosolvan ®).
To study the therapeutic
effect of budesonide
nebulisation in the
therapy of ventilator
associated pneumonia.
To study the effect on
neonatal pneumonia of
aerosol inhalation in
conjunction with
ambroxol budesonide.
Design (Type of
Quantitative, or
Type of
Qualitative)
Qualitative Quantitative Qualitative Qualitative
Setting/Sample NICU of Bangabandhu
Sheikh Mujib Medical
University (BSMMU)/94
neonates
80 newborns Binzhou People’s
Hospital/45 newborns
66 infants
Methods:
Intervention/Instr
uments
Information regarding the
neonates was taken from past
medical history, clinical results,
chest radiography and blood
culture and sensitivity.
Ambroxol inhalation
(Mucosolvan ®)
Budesonide nebulization Combination of aerosol
inhalation and ambroxol
budesonide
Analysis Information regarding the
neonates was taken from past
medical history, clinical results,
chest radiography and blood
culture and sensitivity and SPSS
version 20 have been used to
analyze the test results.
Two-tailed Fisher’s exact t-
test or one-way analysis of
variance (ANOVA),
Tukey’s post-hoc test,
Western blotting and Real
time PCR have been used to
analyze the test results.
SPSS ver. 20, Chi-square
test and Kaplan-Meier
curve have been used to
analyze the test results.
None.
Key Findings The average rate of ill neonates
admitted was 8.4%, which
comprised 34% of suffering
neonates.
Mucosolvan displayed a
good inflammatory reaction
and better lung function.
Moreover, Mucosolvan
was found to inhiit cell
apoptose and NF-
κB pathway activation and
that pulmonary functions
were effectively improved.
Budesonide nebulization
has shown to be effective
in treating the ventilator
associated pneumonia in
newborns and it reduces
the death rate and
enhance pulmonary
diffusion function.
The application of
ambroxol and
budesonide can
efficiently enhance the
functioning of the infant
pulmonary system,
reduce recovery time and
boost hemodynamics of
infants.
Recommendations None. Researchers have
recommended the use of
Mucosolvan.
Budesonide nebulization
has been recommended.
Combination of aerosol
inhalation and ambroxol
budesonide has been
recommended.
Explanation of
How the Article
Supports
EBP/Capstone
The following articles describes
the prevalence of pneumonia in
neonates.
The following article will
reflect upon the Capstone
project as the project is
related to pneumonia.
The following article will
reflect upon the Capstone
project as the project is
related to pneumonia.
The following article will
reflect upon the Capstone
project as the project is
related to pneumonia.
© 2017. Grand Canyon University. All Rights Reserved.

© 2017. Grand Canyon University. All Rights Reserved.