This presentation provides an overview of the neurobiology of autism, focusing on genetic and environmental factors, heterogeneity, and the impact of biological sex. It discusses two research articles that explore the neuroanatomical differences between males and females with autism and the use of the Autism Brain Imaging Data Exchange (ABIDE) to evaluate the intrinsic brain architecture in autism. The presentation concludes with a discussion on the implications of these findings and the need for further research.