Non-Adherence to Bipolar Medication: Contributing Factors and Incidence Among Patients

Running head: BIPOLAR MEDICATION
BIPOLAR MEDICATION
Name of the student:
Name of the university
Author note:
1

BIPOLAR MEDICATION
Methods
The search strategy employed aimed to identify articles that would provide evidence on
the topic of interest, non-adherence to bipolar medication within bipolar patient depending on the
age. The data bases used for the study were EMBASE and PUBMED. The search terms used :
polypharmacy or non, bipolar, mania, patterns of treatment, non-adherence to bipolar medication
and persistence. The finding organized using the PRISMA flow chart ( figure 1).
The eligibility criteria for inclusion study are as follows:
 All articles are taken are peer review journal.
 All Articles are published in English
 All Articles that are extracted on and after the 2013.
 All articles are focused on the non compliance to the bipolar medication
 All articles are focused on the human subjects.
 Articles having the abstracts are included
 Additionally, studies that described non-adherence to pharmacological drugs used to treat
mania and psychosis were included in the study.
The eligibility for the exclusion criteria are as follows:
 All non peer review journal were excluded
 All non English journal were excluded
 All journal focused on the animal model were excluded
 All articles are focused on the non compliance to other psychological disorder other than
bipolar medication can be excluded.
 The articles having clinical guidelines are excluded.
2

BIPOLAR MEDICATION
 articles that explained non- adherence to pharmacological treatment for other mental
health disorders were excluded
 Articles that sought to find out strategies of enhancing adherence to bipolar medication,
cost of managing the illness, the burden of the condition, quality and safety of life and
articles that explained non- adherence to pharmacological treatment for other mental
health disorders were excluded.
The total number of 4450 articles was screened from the databases. After screening and
excluding the duplication of the articles 2125 full texts articles were taken which had abstracts.
1800 articles were screened and excluded 1770 articles. Finally, 30 full text articles were further
reviewed for eligibility based on inclusion criteria and out of this , 8 journals were included for
qualitative study.
3

BIPOLAR MEDICATION
PRISMA Flow Diagram
4
Included
Records identified through
database searching
(n = 4450 )
ScreeningEligibility Identification
Additional records identified
through other sources
(n = 0 )
Records after duplicates removed
(n = 2125 )
Records screened
(n = 1800 )
Records excluded
(n = 1770 )
Full-text articles
assessed for eligibility
n=30 )
Full-text articles excluded,
with reasons
(n = 22 )
 strategies of
enhancing adherence
to bipolar medication
 cost of managing the
illness
 the burden of the
condition
 quality and safety of
life
 non- adherence to
pharmacological
treatment for other
mental health
disorders
Studies included in the
qualitative synthesis
(n = 8 )
Studies included in
quantitative synthesis
(meta-analysis)
(n = 0 )