This essay discusses the challenges faced by nurses in the 21st century and the competencies they need to overcome them. It also evaluates the importance of one of the messages from the Institute of Medicine’s 2010 Future of Nursing report. The challenges include nursing shortage, long working hours, and workplace hazards. The competencies include patient-centered care, interdisciplinary teamwork, evidence-based practice, root cause analysis, and information technology. The essay emphasizes the need for nursing students to upgrade their skills and strive to achieve the five competencies listed by the Institute of Medicine.