This report focuses on the effective management of Type 2 Diabetes Mellitus (T2DM) through lifestyle interventions and insulin injection. It includes a summary of evidence-based research, search strategy, list of articles, and critical appraisal. The report concludes that healthy lifestyle interventions are more effective in managing high blood glucose levels among T2DM patients while reducing other clinical risk factors. The highest level of evidence is a systematic review and meta-analysis.