This article explores the best evidence based practice for the creation of positive therapeutic relationship with patients who belong to diverse cultures. It includes a research question, PICO format, search strategy, hierarchy of evidence, synthesis of articles, critical appraisal tool, and choice of high level of evidence and rationale. The article also discusses the identification of the clinical issue, summary of the evidence base, justification for the choice of research topic, and identification and selection of critical appraisal tool.