(PDF) Adverse reactions of Amiodarone

Page1

TABLE OF CONTENT
S.NO TOPIC PAGE NO.
1 Overview 3
2 Research 6
3 Diagnosis 8
4 Treatments 9
5 policies 11
6 References 12
2 | Page

OVERVIEW
Metabolic manipulators are those agents or factors which manipulate or disturb the metabolic
functions of cells, tissues or body organs(Lange,2012).
Metabolic manipulator which we are going to discuss in this assignment is Amiodarone.
It is an antiarrythmic medication use in the treatment of unusual rhythm of heartbeats.
Its molecular formula is C25H29I2NO3.
IUPAC name if this drug is (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-
diiodophenoxy}ethyl)diethylamine
Molecular mass of this drug is exactly 645.32 g/mol.
Structural formula can be written as-
3 | Page

Class of drug in which it falls is Class III Vaughan Williams Antiarrhythmic agent
The main component of this drug is iodine rich benzofurane. This acts as an antiarrhythmic
agent.
USES OF DRUG
Amiodarone is used in the treatment of
 acute life-threatening arrhythmias
 acute life-threatening arrhythmias
 acute life-threatening arrhythmias
Ventricular tachycardia
Atrial fibrillation
WORKING OF DRUG
Amiodarone is a type of antiarrhythmic drug which help in the treatment of irregular heartbeats
by
Slowing conduction rate of SA node and AV node.
Increasing the refractory period of ventricles, bundle of HIS and purkinjee fibers
By acting as beta blockers a calcium channel blockers to increase the refractory
period.
4 | Page