Obesity and Intestinal Barrier Dysfunction
Added on 2020-02-24
4 Pages497 Words198 Views
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Running Head: OBESITY Obesity Name of the StudentName of the University Author Note
OBESITYIntroductionThe paper deals with the effect of obesity on intestinal barrier function. Further, therelation of obesity to IBD is explained. Effect of obesity on intestinal barrier functionObesity is associated with metabolic alterations in the body such as insulin resistance andglucose intolerance. Metabolic syndrome manifest as low-grade systemic inflammation and isdirectly associated with the intestinal barriers dysfunction. Inflammation is caused by thelipopolysaccharide or LPS derived from the gut microbiota. This factor is associated with themetabolic disease linked to obesity. LPS is the major component of bacterial cell wall (gramnegative bacteria). These bacteria can induce inflammation. Intestinal epithelium acts as barrierin normal physiological conditions and inhibits the LPS translocation (Walters et al. 2014).People with obesity consume high fat diet. The barrier function is changed by the high fat dietdue to reducing thickness of mucous layer. Thus, it is easy for the microbes to destroy the tightjunction protein and destroy the intestinal permeability. Poor permeability allows greater accessof bacteria to intestinal route. It consequently increases the inflammatory process resulting inintestinal tissue injury wall. It results in inflammatory bowel disease or IBD (Seminerio et al.2015). Thus, obesity is associated with IBD. Several experiments conducted with mice modelshowed manifestation of inflammatory bowel disease showed clear defect in epithelial barrierdefects. In mice models, epithelial tight junction proteins were poorly expressed when kept onhigh fat diet (König et al. 2016).
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