This article explores the pathophysiology and pharmacology of ischemic stroke, focusing on the diagnosis, etiology, and risk factors. It discusses the clinical manifestations and treatment options for patients with atrial fibrillation and ischemic stroke.
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1 Running head: PATHOPHYSIOLOGY AND PHARMACOLOGY PATHOPHYSIOLOGY AND PHARMACOLOGY Authors’ name Institution
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2 PATHOPHYSIOLOGY AND PHARMACOLOGY Ischemic stroke is the most common stroke type representing about 85% of all strokes (David, 2009). Recent years have witnessed increasing recognition and interests in stroke as a significant public health problem (David, 2007, pp1). Right-sided facial drooping is a defect caused by having extracranial embolism which has an important renal action that is central to disorder bone metabolism with renal failure. PTH decreases proximal phosphate reabsorption by diminishing the activity of the sodium phosphate cotransporter in the apical membrane (Helmut & Rennker, 2007, p-318). Seward is a patient with atrial fibrillation with a history of hypertension. He is reportedly to be in good condition. In Steward's case, an increase in renin secretion (PTH) decrease caused the weakness in his arm. The ORG 10172 trial in actual stroke treatment classification is commonly used to define the cause o ischemic stroke. Cardin embolic stroke and dissections of cervical or cerebral are the most common etiologies of stroke (Turgut & Lars, 2018). Other defects that Steward had included unconditional gait and dominant visual gaze towards the left which is an eye movement disorder (Martinus). Pathophysiology is the study of how the disease affects the functioning of the body. Risk factors are factors that cause an increased risk of the illness (Sarah A., Justine R. & Vanessa T.). In our patience case, the pathophysiology in the scenario includesright-sided facial drooping, unconditional gait and dominant visual gaze towards the left which after a screening, he was found to be diagnosed with ischemic stress caused by an extracranial embolism. Other onset weakness includes numbness diplopia, dysarthria, vertigo and many more. All diseases involve damage or injury to the cell which makes the cells to stop functioning correctly or death. Cellular communication is one of the pathophysiology causing etiology. Different organs which include tissues and cells must work together to form a fully functioning person. The working together of the cells is called integration. This may be linked with Steward's case of right-sided facial
3 PATHOPHYSIOLOGY AND PHARMACOLOGY drooping (Sarah A., Justine R. & Vanessa T.). The stroke typically involves an absence of functions. An example, our patient reported the loss of sight in an eye. Recent years have witnessed increasing recognition and interest in stroke as a major public health problem (Magdy S.). Imhota, the founder of Egyptian medicine, describes stroke in one of the most ancient diseases in the world. By then, stroke treatment was rudimentary and often nihilistic. Stroke victims might have been treated using maggots or leech to improve the blood movement in the brain (Magdy S.). Despite the modern advances in the diagnosis and treatment of cerebrovascular disease, stroke remains a significant cause of mortality and morbidity worldwide (Rodney ). Stroke mortality rises rapidly with age. The increase in mortality in the elderly is mainly a result of the steep rise in the incidence of stroke with age (Sara T., Mathew F. & Peter M.). Research shows that the diagnosis of stroke can be accelerated by age, where old people are likely to be affected. Two, studies of twins and families with stroke suggest a genetic component to stroke risk (Andrew, Mathew & hunt 2012). Based on the assumption that at list some of the dangers sporadic stroke is genetic, large numbers of studies using different methodologies have been carried out in an attempt the genes involved. There are only a few data relating to a family on stroke severity. Stroke prevention may be targeted at two primary levers which include the mass approach for the population at large and the high-risk approach for those in the population who are believed to be at great risk (Scott E. & Philip B.). The essay has covered patient’s risk factors in relation to Steward's case. The scenario has outlined the diagnosis, etiology and risk factors. Steward has atrial fibrillation which led to him being diagnosed withischemic stroke.On the risk factors, a brief description of the disease is given. The essay has also described the pathophysiology causes in the clinical manifestation
4 PATHOPHYSIOLOGY AND PHARMACOLOGY where stewards brain is already affected. The last bit of the essay has justified the diagnostic investigation and treatment. Helmet, G., & Bradley, M., 2007. Renal pathophysiology: the essentials. David, M. Greer. 2007. Acute ischemic stroke. Retrieved atwww.wily.com/go/permision Turgut, T., &Lars, T., 2018. Ischaemic stroke In youth. oxford Martinus, N., an eye movement disorder. Junk publishers.Doi10/1007/978-94-009-3317- 0 Sarah A., Justine R. & Vanessa T, 2016.Pathophysiology &harmacology for nursing students. Andrew M, et al. (ed). 2012. Hemorrhagic and ischemic stroke. Scott E., & Philip B., 2004. Prevention and treatment of ischemic stroke Sara T., Mathew F. & Petre M, 2014. Cure and treatment of ischemic stroke. Leonard S., 2011. Pathophysiology of heart disease. Franklin H. & Jon C., 2010. Pathophysiology of blood disorders.