Pax 7 Gene Study Assignment

Added on - 21 Apr 2020

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Running head: PAX 7 GENEPax 7 GeneName of the Student:Name of the University:Author’s Note:
1PAX 7 GENETable of ContentsIntroduction.................................................................................................................................................2Describing the gene.....................................................................................................................................2Homology and encode protein.....................................................................................................................2Mechanism action of protein.......................................................................................................................2Pax7 expressional action.............................................................................................................................3Mutation of Pax7 gene and evidence...........................................................................................................3References...................................................................................................................................................5
2PAX 7 GENEIntroductionThe development of skeletal muscle, spinal cord, brain and neural crest is largely influenced nyPax 7 gene. The entire brain consists of Pax 7 gene transcripts in a subset of cells at the initial stage.However, in the later life, the expression of the gene is restricted only to mesencephalon. Pax 7 gene is asequence-specific DNA binding factor, the functional role played by the gene during development ismediated by the selection of the target gene (Xu et al., 2013).Describing the genePax7 gene is one of the significant developmental control genes and is a member of thepaired boxof transcription factors. The major functions of the Pax7 gene is the contribution of the gene in the neuraldevelopment in order to establish dorsal polarity of the neural tube. Additionally, the Pax7 gene helps incontinuous refinement of its expression to the brain nuclei thereby, ensuring regional identity. Pax7 geneis plays a significant role in human diseases and cancers.Homology and encode proteinThe Pax7 gene is highly conserved within a paired box sequence and encodes for a paired DNAbinding domain. This suggest that the Pax7 gene plays a significant role in the transcriptional factor byinfluencing the binding and regulating downstream target genes. The Pax7 gene is categorized by thepresences of 128 amino acid DNA with paired binding DNA with two subunits. The two subunits are theN terminal (PAI) domain and the C terminal (RED) domain.Mechanism action of proteinOne of the significant function of the Pax7 gene is its function in the early neural development inorder to establish dorsal polarity of the neural tube along with continuous refinement of the expression.
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