PHARMACOLOGICAL MANAGEMENT OF NANDROLONE.

Running head: PHARMACOLOGICAL MANAGEMENT OF NANDROLONE
PHARMACOLOGICAL MANAGEMENT OF NANDROLONE
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PHARMACOLOGICAL MANAGEMENT OF NANDROLONE1
Nandrolone is an anabolic steroid, which aids in tissue building process in the body. It
is commonly used to manage anaemia in menopausal women. Nandrolone is injected into the
muscle or fat and not directly administered into the mouth. They are also known by their
chemical name that is 19-nortestosterone as they belong to the class of anabolic steroids
whose biological target is testosterone (Wood & Stanton, 2012). Nandrolone is known to
show high ratio of anabolic activity to androgenic activity. The esters of the Nandrolone has
shown many chemical uses like in ophthalmic solution or in cancer (Guimarães et al, 2017).
Nandrolone decanoate is known to manage anaemia and has shown increase in red cells mass
and haemoglobin. When observed with virilisation and signs of deepened voice it should be
discontinued to prevent irreversible virilisation. In case of drug interactions as Nandrolone
may increase its sensitivity to anticoagulants. Nandrolone works by entering the cell and bind
by activating specific nuclear and androgenic receptors. The pharmacological management of
Nandrolone helps to control a specific medical condition. For the desired pharmacological
management and achieve quality outcome, it is required to understand the drug interactions
and possible side effects (Jogerst, et al, 2016).
Androlone is an anabolic sterios that occurs naturally in the human body, in less
quantities. It increases production and excretion of erythropoietin by urination. It is also
reported to have a direct action on bone marrow. Nandrolone functions by binding to the
androgen receptor to a much higher degree than testosterone, but because of its incapability
to act on the muscle in a way unmediated by the receptor, and has a lesser amount of overall
effect on the growth of muscle (Drugbank.ca, 2019).
Nandrolone functions by binding to the receptor agonist complexes that directs it for
entering to the nucleus and bind to specific nucleotide sequences of the chromosomal DNA.
The binding areas are called hormone response elements that influences the transcriptional
activity of some genes by producing androgen effects (Drugbank.ca, 2019).

PHARMACOLOGICAL MANAGEMENT OF NANDROLONE2
Anabolic steroids like Nandrolone also help in treatment of cachexia which is a
chronic disease. It is also used for the management of anaemia caused by kidney failure
(Horstman et al, 2018). Nandrolone phenyl propionate is used in treatment of breast cancer.
Patient administered with Nandrolone has shown characteristics of increased body mass.
The outcomes of pharmacological treatment using Nandrolone can be analysed by
using results in clinical results. In menopausal women, the clinical efficacy of Nandrolone
can be addressed by addressing the efficacy of the steroid to manage anaemia and
osteoporosis. The pharmacological management results in the efficient management of
anaemia and osteoporosis in menopausal women. (Drugbank.ca, 2019).
Appropriate management in dosage of the drug is important for efficient outcome in
managing the medical condition (Jogerst, et al, 2016). Nandrolone is also known to be abused
by sportsperson as the testosterone gives increased strength also known as doping (Wood &
Stanton, 2012). High dose of nandrolone may pose severe side effects like erectile
dysfunction in males and cardiovascular damage (Toxnet.nlm.nih.gov, 2019). In contrast with
non-pharmacological treatments, pharmacological treatments are more efficient and are
evidence based. In menopausal women aged around 50 years old, nandrolone decreases bone
resorption and increases the mass of the muscles. Thus, the mechanism allows to conserve the
bone which otherwise get degraded. Nandrolone works by increasing the mineral content in
the bone at the proximal, distal radius and at the lumbar spine. Nandrolone aids in decreasing
the vertebral pain by increasing the balance of calcium and mass muscle. With usage the
mobility of the spine is increased. Patients suffering from corticosteroid induced osteoporosis
may also be treated by administration of nandrolone. The therapeutic profile inhibits bone
resorption capacity and aids in temporary increase in formation of bone. Recent studies have
shown to increase bone density in forearm in patient with osteoporosis (Solbach, 2016).
Conventional therapy for treatment of osteoporosis results only in delay of bone loss but