Assignment on Role of Greatwall in Mitosis
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Added on 2020-04-07
Assignment on Role of Greatwall in Mitosis
Added on 2020-04-07
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POLO&CDK1Examining the Role of Greatwall in MitosisRecent studies have shown that critical protein coordination is essential in cell division and these fundamental quantities include phosphatases and kinase. In fact, Greatwall kinase or also known as Gwl plays an essential role in the mitotic process by inactivating PP2A-B55 at the entry point while at the same time promoting phosphorylation. However, the understanding of the primary function of Greawall kinase in the mitotic process is still inadequate. Author’ Name:The cell cycle is not only triggered and driven by the molecular events but also regulated through the use of kinase complex network. Additionally, the present phosphatases also accelerate cell cycle activities in a cyclical order. Moreover, cyclin-dependent kinase one existing in the complex form along with cyclin B helps in the mitosis process (Maiato., 2014 p.134). Thequality promotes nuclear wrapper breakdown, spindle assembly as well as chromosomecondensation. According to Orellana-Garcia et al. (2016, p 95), cyclin B–Cdk1 forms the basis of many regulatory and effector proteins which targets mitosis process. The corresponding components of cyclin B–Cdk1 also known as phosphorylation have to be reversed as a mechanism of allowing for the mitotic exit oncethe process comes to a completion. The study also confirms that protein phosphatase 2A has to employed to necessitate dephosphorylation process, however; the substrate must be admitted in its complex form. Moreover, it is essential toconduct a thorough analysis of nuclear localization before commencing vivo biological function. Gwl gene enhances growth and development of Drosophila, however; the null mutants tend to die immediately the pharate adult stage begins to take place. A Gwl activation lead
to a consequential process in the nucleus, and this is term as translocation in the cytoplasm, and this depends on the phosphorylation. Nuclear exclusion requires Glw cyclin B–Cdk1 phosphorylation, however; the substance may not be useful for the binding process in the Polo. Also, there are two mainlymultiple phosphorylation requirements which include Poloas well as Cdk1, and this ensuresthat Gwl relocalization development has proper timing and happens in a robustness manner in accordance with the physiological importance of the entire process. According to Rangone et al. (2011), Gwl playsan essential role in the mitotic process whenever phosphorylating endosulfine proteins are added to the entry ofthe process. Furthermore, endos have to be present during the cellcycle in both cytoplasm and nucleus, and thus, alterations in the Gwl localization will affect the location phosphorylated endo. Rangone et al. (2011), establishes that endos are definedas small protein and it diffuse when the substance is not bound to other proteins through the existing nuclear pores. However,the study hasn't established the localization dynamics. Endos Phosphorylation directly inhibits PP2A and its efficient compartment in the cytoplasm. Glover (2012 p.123), argued thatmitotic regulators, as well as Gwl relative spatial coordination,are fundamental and equally important in line with their functions. Furthermore, it is clearthat Gwl function losses enhances mitotic defects and at the same have little impact in inhibiting the mitotic entry in thecell types. Also, Gwl-PP2A axis failure in the mitotic switch has considerably affected the mitotic events after the NEBD process. It is also important to select and identify key PP2A-B55 substrates factors which impact on the mitotic process. The substrate has to be protected using Gwl from dephosphorylation based on theirspace, time and regulations (Yaakov et al., 2012 p.124).Model and its ExplanationHowever, cytoplasmic and nuclear are the main and the crucial substrates for the process.Subsequently, prophase Gwl retention delays NEBD from the anaphase inception relative. Therefore, PP2A-B55 plays an essential role since it has to act inthe nuclear before any other substrate such as NEBD can act on the same. On the hand, PP2A-Cdc55 (B55) main function is to antagonized Scc1 cohesion Polo phosphorylation to protect the early chromatid mitosis
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