THE QUESTION AND ANSWERS SITES

Running Head: QUESTION AND ANSWERS
Protein Structure Determination and Answering
Name of the Student:
Name of the University:
Author Note:

QUESTION AND ANSWERS1
Answer 1:
The protein ID: 4TVO describes Malate Dehydrogenase (MDH) in the organism
Mycobacterium Tuberculosis (Rcsb.org, 2020).
Answer 2:
MDH is a fundamental protein for the oxidative mechanisms and an enzyme that is
widely spread throughout living organisms. Using NAD+ or NADP+ as electron acceptor, it
induces the inter-conversion between malate and oxaloacetate (Takahashi-Íñiguez et al.
2016). Amazingly there are few studies in prokaryotes about this enzyme was noted this
enzyme has been studied extensively in eukaryotes only. In addition, the sequencing and
activity of this enzyme are intensively controlled because of the significance of its
mechanism. Through information regarding its activity, cofactor attachment power, substrate
sensitivity, and thermostability, this structural knowledge can help to make direct alterations
to enhance the enzyme reaction kinetics. This reaction plays a significant role within the
mitochondrial matrix in the malate / aspartate transfer throughout the mitochondrial
membrane, and even in the tricarboxylic acid cycle.