The course focuses on building a story as a key skill for Data Science, emphasizing effective storytelling by drilling down to fine-grained details and staging messages for downstream points. The importance of relevant data storytelling is highlighted, with an emphasis on getting beyond platitudes and 'motherhood & apple pie.' Course correlations include SDLC vs. SDM, where the professor describes standard phases that systems go through from inception to retirement, and methodologies that manage those phases differently. Big Data is positioned as a primary focus for the course.