Exploring Stem Cell Research: Attitudes, Future Perspectives, and Regenerative Medicine Potential

In this document we will discuss about Exploring Stem Cell Research and below are the summary points of this document:- Stem cell research: Examining public attitudes towards acceptance, influenced by religion, morals and ethics. Future perspectives: Stem cell therapy holds promise for cardiac patients and various chronic diseases. Wound healing and regenerative medicine: Exploring the potential of stem cell-based therapies in enhancing cutaneous regeneration.

Running Head: ANNOTATED BIBLIOGRAPHY 1
STEM CELL RESEARCH
Name
Tutor
Institution
Date of Submission

ANNOTATED BIBLIOGRAPHY 2
Topic and Issue
Topic: Stem Cell Research; Issue: Should the Stem Cell Research be accepted?
Allum, N., Allansdottir, A., Gaskell, G., Hampel, J., Jackson, J., Moldovan, A., ... &
Stoneman, P. (2017). Religion and the public ethics of stem-cell research: Attitudes
in Europe, Canada and the United States. PloS one, 12(4), e0176274.
The authors are researchers in various organizations in Europe and USA such as
Fondazione Toscana Life Sciences in Italy and London School of Economics- Department of
Methodology. They conducted a survey from North America and Europe regarding their view
on stem cell research. They realized that various factors such as religion, morals, ethics, and
public opinion influence the altitude of the people significantly on stem cell research. Most of the
people supported the stem cell research claiming that it offers several benefits in the healthy
system provided the process is tightly regulated. They found that although many religious people
approved the process in all the countries, the citizens of US approved it on the basis of religious
convictions as compared to Europe and Canada. Most of the data collected during the survey
showed that the people’s opinions were tied closely to their religion and moral authority.
Nevertheless, although there was a varying degree between these three nations on acceptability
of stem cell research, they all believed the benefits outweigh the challenges. Therefore, the
article offers supportive information regarding the argument that stem cell research should be
accepted.
Brunt, K. R., Weisel, R. D., & Li, R. K. (2012). Stem cells and regenerative medicine—
future perspectives. Canadian journal of physiology and pharmacology, 90(3), 327-
335.

ANNOTATED BIBLIOGRAPHY 3
The authors, researchers from the Heart and Stroke Foundation of Canada analyzed the
transition of stem cell research from the 20th to the 21st century. They discovered that there was a
need to move from the first-in-man trials to a more definite retrospective use of autologous stem
cell therapy especially in the recovery of the cardiac patients. They found that there was a bright
future for the patients suffering from chronic diseases such as cancer, multiple sclerosis,
muscular dystrophy, type 1 diabetes, Parkinson’s disease, and amyotrophic lateral sclerosis due
to the discovery of novel techniques by various scientists as a result of stem cell research.
Therefore, this source is very useful as it gives a new understanding on how the stem cell
research offers a new promise on the field of clinical therapy and how various research
collaborations between epidemiological and biological institutions could go a long way in
improving the patient’s stem cell health.
Duscher, D., Barrera, J., Wong, V. W., Maan, Z. N., Whittam, A. J., Januszyk, M., &
Gurtner, G. C. (2016). Stem cells in wound healing: the future of regenerative
medicine? A mini-review. Gerontology, 62(2), 216-225.
The authors are from the Division of Plastic and Reconstructive Surgery and Biomedical
Informatics in the Stanford and John Hopkins University and Department of Surgery (Victor W.
Wong) in the United States of America. They demonstrated how stem-cell based therapies have a
positive impact in enhancing cutaneous regeneration, especially in aged skin. Usually, as you
age, there is increased risk of diseases, as well as decreased response to the tissue insult leading
to impaired wound healing. The authors together with their research team have optimized the
progenitor cell selection and delivery of stem cell-based therapies in the treatment of chronic
wounds in aged patients such as bio-scaffold based approaches and microfluidic single cell
characterization. As such, this article offers essential information on how stem cell research
provides a promising approach to chronic would therapy in aged patients particularly through the

ANNOTATED BIBLIOGRAPHY 4
release of cytokines and soluble growth factors that modulate inflammation, hence new vessel
formation.
Hellmers, N., Obeng-Aduasare, Y., de Melo-Martín, I., & Henchcliffe, C. (2016). Future
needs for informed consent in stem cell clinical trials in neurodegenerative diseases.
Neural regeneration research, 11(1), 83.
The authors are researchers at Weil Cornell Parkinson’s Disease and Movement
Disorders Institute and Division of Medical Ethics, Weill Cornell Medical College, USA. The
authors aimed to bring forth the importance of informed consent for all the participants of stem
cell research in clinical trials using humans. They indicate that there is a need for free disclosure
of information without holding any single detail. Failure to do so would affect the research either
directly or indirectly. For instance, if a participant realizes that there was information that was
withheld, he/she might withdraw thereby affecting the results. Therefore, it is crucial for all the
concerned teams such as bioethicists, psychiatrists, local Institutional Review Boards (IRBs), and
clinical research teams to ensure informed consent is given. As such, this source offers crucial
information in supporting the argument that stem cell research should be accepted as informed
consent is key.
Hongbao, M., & Shen, C. (2007). Eternal Life and Stem Cell. Nature and science, 5(1), 81-
96.
Ma Hongbao is a researcher based at the Brookdale Hospital, Brooklyn, in New York,
USA while Cherng Shen is a researcher in the Department of Electrical Engineering, Chengshiu
University, China. The authors in this article demonstrated how the injection of Germline Stem
Cell (GSC), into an adult human body can induce a possibility of eternal life. Normally, the stem
cell is the progenitor of all cells. Therefore, the authors aimed to determine whether research on
stem cells through introduction of GSC into an old person can renew their life. They have shown

ANNOTATED BIBLIOGRAPHY 5
that stem cells can rejuvenate and replenish damaged cells as well as repair themselves and those
of their neighbors. Further, they addressed the need to protect participants and the donors during
the clinical trials such as in Phase I. As such, the source is very helpful in offering insights on
why it is important to protect the participants while researchers are performing the research on
stem cell.
Knoppers, B. M., Isasi, R., Caulfield, T., Kleiderman, E., Bedford, P., Illes, J., ... &
Rudnicki, M. (2017). Human gene editing: revisiting Canadian policy.
The authors are researchers at McGill University- the Centre of Genomics and policy,
Canada, Hussman Institute for Human Genomics, Miami, USA, Ottawa Hospital Research
Institute, and Department of Cellular and Molecular Medicine, Ottawa, Canada. The authors
were scrutinizing the regulatory and ethical policies that were necessary in the application of
stem cell technologies. The evolution experienced in the use of various gene editing technologies
calls for socio-ethical and legal policies. In the year 2004, the Canadian government
implemented an Act, Assisted Human Reproductive (AHR), that prohibits a number of activities
such as embryo creation, in vivo and in vitro germ line alterations, and gene-editing. The authors,
however, have indicated the importance of Canada in allowing human gene editing as they
would benefit greatly from the advancement of stem cell research. Therefore, the article offers
crucial information regarding why stem cell research should be allowed and legalized in Canada
as it would significantly improve the health of the people.
Mahla, R. S. (2016). Stem cells applications in regenerative medicine and disease
therapeutics. International journal of cell biology, 2016.
Ranjeet Mahla is a researcher at the Indian Institute of Science Education and Research
(IISER). The authors in this article show the benefits that have been obtained from the field of
stem cell research. Many diseases that can’t be cured by the available conventional medicines

ANNOTATED BIBLIOGRAPHY 6
have experienced a light from the cell-based therapies. Advancements realized in tissue
engineering technology and gene editing have improved the ex vivo remodeling of several stem
cells into 3D organoids for personalized applications. Use of various types of stem cells in
regenerative medicine has improved the health of people to a larger extent. Therefore, this source
will support immensely the argument why stem cell research should be accepted.
Ng, A. P., & Alexander, W. S. (2017). Hematopoietic stem cells: past, present and future.
Cell death discovery, 3, 17002.
The authors are researchers in the Medical Biology Department at the University of
Melbourne and the Walter and Eliza Hall Institute of Medical Research, Australia. They aimed to
investigate how research on stem cell can be improved in the future such as genome editing. In
the coming years, stem cell research is engineered towards developing robust methods that will
effectively correct any defective disorder. Challenges that were being experienced in a couple of
years back, in the field of medical therapy are being sorted by advanced research in stem cell
studies. There is a bright future in the field of stem cell research through the discovery of novel
outcomes, hence, continual treatment improvements. Therefore, this source contains detailed
information which supports the significance of stem cell research.
Tani, J., & Umbas, R. (2009). Recent progressions in stem cell research: breakthroughs
achieved and challenges faced. Acta Med Indones, 41(1), 30-35.
The authors are researchers based at the University of Indonesia- Faculty of Medicine.
Stem cell research has been faced with several difficulties. The authors aimed to show the
progress this field has attained over the recent years. They include the Somatic-Cell Nuclear
Transfer (SCNT) and pluripotent stem cell induction which enhance the generation of new stem
cell lines that allow patient-specific transplantation therapy. They have demonstrated how the
research has progressed from using animal models such as rats and mice to using human

ANNOTATED BIBLIOGRAPHY 7
participants in clinical trials. Through the use of these techniques stem cell research has been
able to play a huge role in improving therapy of hematological diseases such as lymphoma and
leukemia. The dependence limits which has been observed for long in donor bone marrow
transplant has been overcome by use of induced pluripotent stem cell. Therefore, this article
offers supportive evidence on why stem cell research should be accepted as it enhances treatment
of various disorders such as heart damage, hematopoietic system, and cartilage defect in humans.
Trounson, A., & McDonald, C. (2015). Stem cell therapies in clinical trials: progress and
challenges. Cell stem cell, 17(1), 11-22.
The authors are researchers at the Hudson Institute for Medical Research based in
Australia. The authors aimed to determine the safety issues arising from the use of stem cell
products in regenerative medicine through autologous and allogeneic transplants. Use of stem
cells has been approved in several countries globally such as mesenchymal stem cells in pediatric
graft disease in Canada and New Zealand and Limbal stem cells in the treatment of eye burns in
Europe. Furthermore, the authors indicated why some failures has been experienced in the field
of stem research. This could be as a result of insufficient scientific data and insufficient clinical
benefit especially in Phase II of clinical trials which hinder Phase III and IV studies. However,
despite the challenges experienced, more advancement in stem cell research is being seen, which
necessitates further stronger scientific evidence. This source, therefore, is very vital in relation to
supporting the argument why the stem cell research should be accepted.

ANNOTATED BIBLIOGRAPHY 8
References
Allum, N., Allansdottir, A., Gaskell, G., Hampel, J., Jackson, J., Moldovan, A., ... & Stoneman,
P. (2017). Religion and the public ethics of stem-cell research: Attitudes in Europe,
Canada and the United States. PloS one, 12(4), e0176274.
Brunt, K. R., Weisel, R. D., & Li, R. K. (2012). Stem cells and regenerative medicine—future
perspectives. Canadian journal of physiology and pharmacology, 90(3), 327-335.
Duscher, D., Barrera, J., Wong, V. W., Maan, Z. N., Whittam, A. J., Januszyk, M., & Gurtner, G.
C. (2016). Stem cells in wound healing: the future of regenerative medicine? A mini-
review. Gerontology, 62(2), 216-225.
Hellmers, N., Obeng-Aduasare, Y., de Melo-Martín, I., & Henchcliffe, C. (2016). Future needs
for informed consent in stem cell clinical trials in neurodegenerative diseases. Neural
regeneration research, 11(1), 83.
Hongbao, M., & Shen, C. (2007). Eternal Life and Stem Cell. Nature and science, 5(1), 81-96.
Knoppers, B. M., Isasi, R., Caulfield, T., Kleiderman, E., Bedford, P., Illes, J., ... & Rudnicki, M.
(2017). Human gene editing: revisiting Canadian policy.
Mahla, R. S. (2016). Stem cells applications in regenerative medicine and disease therapeutics.
International journal of cell biology, 2016.
Ng, A. P., & Alexander, W. S. (2017). Hematopoietic stem cells: past, present and future. Cell
death discovery, 3, 17002.
Tani, J., & Umbas, R. (2009). Recent progressions in stem cell research: breakthroughs achieved
and challenges faced. Acta Med Indones, 41(1), 30-35.

ANNOTATED BIBLIOGRAPHY 9
Trounson, A., & McDonald, C. (2015). Stem cell therapies in clinical trials: progress and
challenges. Cell stem cell, 17(1), 11-22.