Report on Materia Medica

Added on - 21 Apr 2020

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1Running head: MATERIA MEDICAMateria MedicaName of student:Name of university:Author note:
MATERIA MEDICAIntroductionThe action category that has been selected for the present report is Laxatives. Thethree herbs that would be considered for the assignment are Senna Alexandrina, FrangulaPurshiana and Rheum Palmatum, a comparison and contrast between whom would be thesubject of the report.Senna Alexandrina• Medicinally active plant part- The dried leaflets and dried fruits of the plant are used formedicinal purpose.• Active constituents- The active ingredients are the numerous Senna glycosides,steroisomers of Sennoside A and B. They are glycosides of arhein anthronemolecule,binding to each other in pairs. Other than this the other bioactive molecules are Emodin,Aloe-emodin, Flavonoids and Napthalene(Ajayi et al., 2014).• Secondary herbal actions and mechanisms of action- The drug acts by acting with theimmune cells in the colon. There are two mechanisms by which the Senna products exertspro-motility effects. Stool softening effects are undertaken by modifying the intestinalcontractions for favouring peristalsis and by inducing the excess secretion of electrolytes intothe colon which increases the water content of the colon.• Therapeutic indications- It is used as a laxative. The drug is effective in clearing the bowelsand also possess action capability due to which it is used at times before a colonoscopy. Inaddition, it acts as a fungicide.• Potential safety issues ie: cautions, contra-indications and interactions- If this herb isaccidently consumed by infants, it leads to serious side effects such as severe diaper rash.
MATERIA MEDICAGastrointestinal cramps are rare. Prolonged ingestion can lead to electrolyte balance andpresence of protein and blood in the urine.• Preparation- The herb is used in the form of chopped leaves or powdered leaves. Inaddition, it can also be used as herbal tea (Tomlinson & Akerele, 2015).• Dosage recommendations- For proper clinical usage, the accurate dose required forproducing the desired effect is the lowest dose. This is indicated by comfortable and sost-fromed stool. This refers to 1-2 gm of the powdered extract standardised to 10-30 mg activeSennosides.Frangula Purshiana• Medicinally active plant part- The bark of the plant is used as a very effective laxative.• Active constituents- The constituens that are chiefly responsible for the medicinal action arethe Emodin and hydroxyanthracene glycosides.• Secondary herbal actions and mechanisms of action- A number of quinoid substances arefound in the bark of the plant. The hydroxyanthracene glycosideshave the herbal ation byworking as a stimulant laxative. The peristalsis in the colon is excited by these stimulanteffects. This thereby triggers peristalsis through inhibiton of the absorption of electrolytesand water in the large intestine. As a result of this action, the volume of the bowel’s contentincreases, giving rise to increased pressure.• Therapeutic indications- The main use of the herb is as a laxative. Some studies have shownthe anti-cancer effects of the drug(Cirillo & Capasso, 2015).
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