Signs and Symptoms of Paraquat Poisoning

Added on - 21 Apr 2020

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Running head: GENERAL TOXICOLOGYTOXIC EFFECT OF PARAQUAT ON THE LUNGSName of the StudentName of the UniversityAuthor note
GENERAL TOXICOLOGY1Table of ContentsIntroduction..........................................................................................................................2Mechanism of paraquat toxicity..........................................................................................2Signs and symptoms of paraquat poisoning........................................................................3Reason for lung being the prime target................................................................................4Conclusion...........................................................................................................................5References............................................................................................................................6
GENERAL TOXICOLOGY2IntroductionParaquat, which is generally known as its systematic name 1'-dimethyl-4, 4’-bipyridinium Dichloride is a quaternary nitrogen compound. It is generally present as the salt,which is odorless and colorless. It is used as herbicide, and is one of the most toxic herbicideused over the last 50 years. This herbicide is banned or disallowed in more than 32 countries dueto its adverse effects on humans as well as animals. This herbicide possesses redox activity thatproduces superoxide anions, which is harmful for the health of humans (Blanco-Ayala,Andérica-Romero & Pedraza-Chaverri, 2014). Paraquat is an oxidant that creates superoxidemolecules in the presence of oxygen. These superoxide molecules are harmful for mammals, asthese molecules scavenges the immune cells present in the blood stream. Further, the metabolicand skin related disorders resulting from ingestion of paraquat also leads to several healthcomplications. These complications results in the death of the victim.This assignment is will focus on the toxic ability of Paraquat and will explain the wayParaquat can enhance toxicity with the help of reactive oxygen and metabolism. Further, theclinical signs and symptoms paraquat poisoning are going to be explained. Finally, themechanism, by which lungs become infected of paraquat are going to be discussed.Mechanism of paraquat toxicityAfter ingestion, paraquat becomes highly toxic to humans and animals and causes AcuteRespiratory Distress Syndrome (ARDS). It is the toxicant where inhalation for lung infection isnot mandatory and consumption of this substance leads acute lung infection. This Toxicant hasbeen listed in the toxicity category one, which is highest among the four toxic categories. Thesalt form of paraquat, which is used for the agriculture purpose are greater than inhaled capacity
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