Asset managers in healthcare environments face multiple challenges, including financial constraints, maintaining patient safety, and hospital security. The exponential growth of data volume requires automation of e-science processes, digitalization of artefacts, and advanced security technologies to ensure secure operation of research infrastructures. Big Data implementation in healthcare can accelerate decision-making, create transparency, enable experimentation, and bring innovation via new business models. To optimize asset utilization through the use of Big Data, improvements steps include setting aside traditional mindsets, embracing new approaches, promoting data sharing with appropriate protections, and collaboratively working toward better outcomes at lower costs.