Evaluating Warfarin and New Anticoagulant for DVT Prevention
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Added on 2020/10/22
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The assignment explores the comparison of Warfarin with a newly developed anticoagulant drug for preventing blood clotting and DVT. It examines the study design, population source, selection bias considerations, misclassification, and confounding factors relevant to this research topic.
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Table of Contents Study Design....................................................................................................................................3 Study Hypothesis.............................................................................................................................3 Methodology...................................................................................................................................3 Primary outcome measure......................................................................................................3 Population Source...................................................................................................................3 Selection Bias Considerations..........................................................................................................3 Misclassification..............................................................................................................................3 Confounding Factors........................................................................................................................4 REFERENCES................................................................................................................................4
Study Design Interventional Study; RCT Management category - Parallel Design Study Hypothesis Comparison of Warfarin with newly developed anticoagulant drug(A) for preventing blood clotting and DVT in terms of their effectiveness (Kahn and et. al., 2014). Methodology Primary outcome measure Observation of patients suffering from Deep Vein Thrombosis (DVT) due to different causes such as obesity, paralysis, injury or surgery etc. Population Source Major areas of population who has been affected with DVT includes inheriting a blood clotting disorder, paralysed individuals, pregnant women, fliers (Deep vein thrombosis (DVT), 2018). Thus, this group of 100 patients are observed thoroughly as per their symptoms or cause of DVT to analyse effectiveness of new manufactured drug for the same. Additionally, it can be possible to blind sonography takers and patients to gain more fair and accurate results. Thus, such people also have certain risk including post phlebitic syndrome and pulmonary embolism. Selection Bias Considerations There are criteria’s to select only presently suffered individuals with the given health problems relevant to different causes. It also indicates to kept in mind about their current symptoms like sudden shortness in breathing, chest pain, fainting, rapid pulse and coughing up blood (Declan Devane and Dip, 2011). However, a biasness is created here due to selecting people for research in terms of considering some specific symptoms and select current patient of same problem. Moreover, several factors are avoided such as age, gender, duration of remain admitted etc.
Misclassification The mistakes can occur due to negligence of pathologist or sonography taker while conducting check-up and provide result with errors. It can be considered about measurement errors of outcome which may facilitates misclassification of population taking for research. Confounding Factors In this study, several symptoms are confounding because they are similar to signs of DVT but actually not relevant to the same (Shapiro, Vogel and Kiran, 2011). It includes swelling of leg, pain or tenderness, red or discoloured skin etc. REFERENCES Books and journals Kahn, S. R. and et. al., 2014. Graduated compression stockings to treat acute leg pain associated with proximal DVT.Thrombosis and haemostasis. 111(06). pp.1137-1141. Declan Devane, R. G. N. and Dip, H. E., 2011. Methodological considerations in cohort study designs.Nurse Researcher (through 2013). 18(3). p.32. Shapiro, R., Vogel, J. D. and Kiran, R. P., 2011. Risk of postoperative venous thromboembolism after laparoscopic and open colorectal surgery: an additional benefit of the minimally invasive approach?.Diseases of the Colon & Rectum. 54(12). pp.1496-1502. Online Deepveinthrombosis(DVT).2018.[Online].Availablethrough: <https://www.mayoclinic.org/diseases-conditions/deep-vein-thrombosis/symptoms- causes/syc-20352557>