Synthesis of Research Findings | Report
Added on 2022-09-15
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Running head: WORKSHEET
Synthesis of Research Findings
Name:
Faculty:
Date:
Synthesis of Research Findings
Name:
Faculty:
Date:
WORKSHEET1
Synthesizing Questions: Identify and succinctly state the following related to the sum of the
evidence in your identified articles. Use APA format for citations as appropriate when referring
to specific articles.
**Key Question**
RCT Article (citation) CPG (citation) Qualitative (citation)
In healthy
postmenopausal women
with symptoms of
vaginal atrophy, how
does vaginal estrogen
compared to vaginal
moisturizer alleviate
discomfort?
Mitchell, C. M., Reed,
S. D., Diem, S., Larson,
J. C., Newton, K. M.,
Ensrud, K. E., ... &
Guthrie, K. A. (2018).
Efficacy of vaginal
estradiol or vaginal
moisturizer vs placebo
for treating
postmenopausal
vulvovaginal
symptoms: a
randomized clinical
trial. JAMA internal
medicine, 178(5), 681-
690.
Stuenkel, C. A., Davis,
S. R., Gompel, A.,
Lumsden, M. A.,
Murad, M. H.,
Pinkerton, J. V., &
Santen, R. J. (2015).
Treatment of symptoms
of the menopause: an
endocrine society
clinical practice
guideline. The Journal
of Clinical
Endocrinology &
Metabolism, 100(11),
3975-4011.
Utian, W. H., &
Maamari, R. (2014).
Attitudes and
approaches to vaginal
atrophy in
postmenopausal
women: a focus group
qualitative
study. Climacteric, 17(1
), 29-36.
Synthesizing Questions: Identify and succinctly state the following related to the sum of the
evidence in your identified articles. Use APA format for citations as appropriate when referring
to specific articles.
**Key Question**
RCT Article (citation) CPG (citation) Qualitative (citation)
In healthy
postmenopausal women
with symptoms of
vaginal atrophy, how
does vaginal estrogen
compared to vaginal
moisturizer alleviate
discomfort?
Mitchell, C. M., Reed,
S. D., Diem, S., Larson,
J. C., Newton, K. M.,
Ensrud, K. E., ... &
Guthrie, K. A. (2018).
Efficacy of vaginal
estradiol or vaginal
moisturizer vs placebo
for treating
postmenopausal
vulvovaginal
symptoms: a
randomized clinical
trial. JAMA internal
medicine, 178(5), 681-
690.
Stuenkel, C. A., Davis,
S. R., Gompel, A.,
Lumsden, M. A.,
Murad, M. H.,
Pinkerton, J. V., &
Santen, R. J. (2015).
Treatment of symptoms
of the menopause: an
endocrine society
clinical practice
guideline. The Journal
of Clinical
Endocrinology &
Metabolism, 100(11),
3975-4011.
Utian, W. H., &
Maamari, R. (2014).
Attitudes and
approaches to vaginal
atrophy in
postmenopausal
women: a focus group
qualitative
study. Climacteric, 17(1
), 29-36.
WORKSHEET2
NOTE: *The answer to this question will impact the “weight” you put into the findings of this
article for synthesis and dissemination. If you determine it is NOT a strong article
methodologically, do not use its findings as recommendations for patient care.*
NOTE: *The answer to this question will impact the “weight” you put into the findings of this
article for synthesis and dissemination. If you determine it is NOT a strong article
methodologically, do not use its findings as recommendations for patient care.*
WORKSHEET3
Strengths: What are 3 strengths related to this collection of evidence? Think about your critical
appraisals, including the methodology, and presentation of results. Findings of an article are
NOT a strength. At least 2 articles need to share each strength. Give a rationale for why this is a
strength, acknowledging the JBI or AGREE appraisal.
Strength APA
Citations
of Articles
that share
this
strength
(at least 2
for each
strength)
JBI or
AGREE
tool item
or
concept
from
appraisal
Rationale for why
this is a strength-
why this item is
important.
Tie Strength into
article specifics.
(cite from the
article here)
Exampl
e
The samples
were well
described at
baseline and
findings are
generalizable
to the general
population
RCT
citation
Qual
citation
JBI RCT:
Were
treatment
groups
similar at
baseline?
JBI Qual:
Are the
participan
It is important if
these findings are
to be applicable to
the current PICO
question that the
sample is well
described and
generalizable.
This increases the
The RCT article
described the two
groups well at
baseline and noted
differences in
educational level
only.
The Qual article
ensured that the
Strengths: What are 3 strengths related to this collection of evidence? Think about your critical
appraisals, including the methodology, and presentation of results. Findings of an article are
NOT a strength. At least 2 articles need to share each strength. Give a rationale for why this is a
strength, acknowledging the JBI or AGREE appraisal.
Strength APA
Citations
of Articles
that share
this
strength
(at least 2
for each
strength)
JBI or
AGREE
tool item
or
concept
from
appraisal
Rationale for why
this is a strength-
why this item is
important.
Tie Strength into
article specifics.
(cite from the
article here)
Exampl
e
The samples
were well
described at
baseline and
findings are
generalizable
to the general
population
RCT
citation
Qual
citation
JBI RCT:
Were
treatment
groups
similar at
baseline?
JBI Qual:
Are the
participan
It is important if
these findings are
to be applicable to
the current PICO
question that the
sample is well
described and
generalizable.
This increases the
The RCT article
described the two
groups well at
baseline and noted
differences in
educational level
only.
The Qual article
ensured that the
WORKSHEET4
ts and
their
voices
adequatel
y
represente
d?
validity of the
work.
voices of all
participants were
heard by utilizing
numerous
researchers to
analyze the
transcripts.
1. Determined
the short term
effectiveness
of
recommended
hormonal
vaginal
therapies for
management
of
postmenopausa
l vulvovaginal
symptoms.
Mitchell et
al. (2018)
Stuenkel
et al.
(2015)
AGREE
domain 1:
scope and
purpose-
The
health
question(s
) covered
by the
guideline
is (are)
specificall
y
described
?
Determining the
impact of
hormonal vaginal
therapies is
significant owing
to the fact that
after the onset of
menopause, the
level of the
estrogen hormone
becomes
considerably low,
in addition to
thinning of the
vaginal lining,
which
The RCT measured
vaginal mucosal
cell maturation
owing to effects of
estrogen. In
addition the RCT
stated that
hormonal therapy
helped in
increasing the pH
of the vaginal cells
and also increased
VMI superficial
cells.
The guideline
suggested that
ts and
their
voices
adequatel
y
represente
d?
validity of the
work.
voices of all
participants were
heard by utilizing
numerous
researchers to
analyze the
transcripts.
1. Determined
the short term
effectiveness
of
recommended
hormonal
vaginal
therapies for
management
of
postmenopausa
l vulvovaginal
symptoms.
Mitchell et
al. (2018)
Stuenkel
et al.
(2015)
AGREE
domain 1:
scope and
purpose-
The
health
question(s
) covered
by the
guideline
is (are)
specificall
y
described
?
Determining the
impact of
hormonal vaginal
therapies is
significant owing
to the fact that
after the onset of
menopause, the
level of the
estrogen hormone
becomes
considerably low,
in addition to
thinning of the
vaginal lining,
which
The RCT measured
vaginal mucosal
cell maturation
owing to effects of
estrogen. In
addition the RCT
stated that
hormonal therapy
helped in
increasing the pH
of the vaginal cells
and also increased
VMI superficial
cells.
The guideline
suggested that
WORKSHEET5
demonstrates a
reduced number of
folds. Therefore,
the flexibility of
the vaginal lining
decreases and
vaginal secretions
get reduced. This
eventually leads to
a decrease in
lubrication. Hence,
investigating the
impacts of both the
types of therapy
was helpful since
the vaginal region
requires sufficient
amount of estrogen
hormone for
maintaining
integrity of the
tissues (Tiidus,
2017). In addition,
vaginal estrogens
when applied in
low dosage were
able to effectively
alleviate the
symptoms rapidly
such as, vaginal
dryness,
dyspareunia,
dysuria and urge
incontinence.
demonstrates a
reduced number of
folds. Therefore,
the flexibility of
the vaginal lining
decreases and
vaginal secretions
get reduced. This
eventually leads to
a decrease in
lubrication. Hence,
investigating the
impacts of both the
types of therapy
was helpful since
the vaginal region
requires sufficient
amount of estrogen
hormone for
maintaining
integrity of the
tissues (Tiidus,
2017). In addition,
vaginal estrogens
when applied in
low dosage were
able to effectively
alleviate the
symptoms rapidly
such as, vaginal
dryness,
dyspareunia,
dysuria and urge
incontinence.
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