Systematic review and meta-analysis of the
benefit of the radiotracer used in evaluation of
bone metastases in paediatric with neuro-
blastoma
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Introduction
Bone metastasis takes place when the
malignant cells transferred from the
primary affected area to the bones
(Macedo et al., 2017). One of the main
types of cancer is neuro-blastoma
(Matthay et al, 2016) which develops
from the immature nerve cells present
in different parts of the body
(Stanfordchildrens.org 2019). This
particular systematic review will
discuss about the effective tracer to
detect bone metastasis
Bone metastasis (Source; Martin, 2019)
Methods
Different resources like
medline/Pubmed /Embase/Cochrane
library has been searched
Results
TC-99m MDP bone scintigraphy
• Sensitivity identified in research
articles: 94.40%, 70.60%, 86.0%,
32%
• Specificity : 77.80%, 91.1%, 48%,
81.4%, 96%
FDG PET
• Sensitivity: 100%, 93.40%, 98%,
96.8%, 79%, and 42.9%
final synthesis of the mean specificity of the
studies
Conclusions
PET scan is recognised as the finest
technique. 18 NaF is the better choice
compared to other types of imaging
techniques 18 NaF imaging approach
is the best available choice suitable for
the diagnosis of bone metastasis.
References
• Stanfordchildrens.org (2019). default -
Stanford
Children's Health. Stanfordchildrens.org. [Online]
Available from:
https://www.stanfordchildrens.org/en/topic/default?
id=neuroblastoma-90-P02735 [Accessed 20 Jun.
2019].
• Macedo, F., Ladeira, K., Pinho, F., Saraiva, N., Bonito,
N., Pinto, L. and Gonçalves, F., 2017. Bone
metastases: an overview.
Oncology reviews,
11(1).
• Martin, L., 2019. What bone metastasis looks like
[online]. Available from:
https://www.webmd.com/cancer/ss/slideshow-cancer-
bone-metastasis [Accessed 20 July 2019].
Final Synthesis of the mean sensitivity of the
studies

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Systematic review and meta-analysis of the benefit of the

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