MENTAL HEALTH2 Introduction The use of psychotropic medication on an individual with mental health problems has been practiced for decades, with healthcare professionals in the psychiatric setting using them to manage the aggressive behaviors of the patients. Despite, its common use recent research has critiqued its effectiveness and safety in controlling behaviors and managing symptoms for psychiatric patients. Registered nurses have complained about the challenges they experience while administering such drugs to mentally sick patients. There is, therefore, a need to further explore the existing controversy surrounding the use of psychotropic medication in a psychiatric setting. The current paper will examine the proponents and opponents of the use of psychotropic drugs and the existing conflict. The challenges experienced by psychiatric nurses while administering psychotropic drugs will as well be explored. Proponents of Psychotropic Medications Psychotropic drugs have been useful for decades by the healthcare professionals to manage difficult behaviors in mental healthcare settings. The use of psychotropic drugs has been found to be more beneficial than the associated risks. Patients diagnosed with schizophrenia and other mental health complications manifested positive outcomes than harm when given psychotropic drugs. Neuroimaging studies and randomized clinical trials show significant benefits in the treatment of schizophrenia using antipsychotic medication. The patients benefited after an initial prescription and the relapse prevented through long-term treatment (Goff et al., 2017). Studies have also shown that withholding or delaying medication leads to poor long-term effects (Columbia University Medical Center, 2017). The increasing use of psychotropic drugs
MENTAL HEALTH3 for over pharmacological treatments is sufficient evidence of its benefits. SSRIs and tricyclic antidepressants are more effective but SSRIs are much safer, better borne by patients, and much simple for physicians to prescribe because of their basic dosing schemes. Psychotropic medications also reduce the risk of overdose, and the side effects are insignificant and manageable (Gordon & Melvin, 2013). The most recent meta-analysis reported 10% lower overall dropouts during clinical trials among patients taking SSRIs than those who received TCAs prescription. The dropouts due to side effects was 25% lower with SSRIs than the placebo (Qin et al., 2014). The greater willingness by clinicians to prescribe psychotropic drugs to mentally ill patients is evidence of its benefit in improving the quality of healthcare and access. Over 63% of hospital visits to mental health care centers in the United States received psychotropic medication. Most of these visits were handled by primary care physicians who preferred to use psychotropic medications due to their safety and ease of dosing (Sheehan et al., 2015). The global use of psychotropic drugs for decades implies that the global regulatory agencies have conducted tests and ensured that they are licensed, safe and the benefits far outweigh the possible harms. This is more reliable, unlike population-based studies in which the participants might have varying medical conditions (Gøtzsche, Young, & Crace, J2015). New long-term data have displayed an inverse association between death rate and cumulative use of psychotropic medication. There is evidence of a low death rate in the use of psychotropic medication compared to the placebo. Similar outcomes were obtained by Angst et al. (2013) who explored the impacts of psychotropic treatment on the death rate of patients diagnosed with an anxiety disorder. The researchers followed up to 400 patients with affective disorders for over 20 years. After 30 years, only 76% of them had succumbed. The study
MENTAL HEALTH4 reported significantly lower suicide rates in all the groups. Based on the above evidence, psychotropic drugs are thoroughly tested for efficacy and safety before and after the approval of concerned bodies. The existing studies that critique the benefits of psychiatric drugs is imperfect cannot fully be relied upon. Opponents of Psychotropic Medications The long-term use of psychotropic medication has been found to cause adverse side effects. Critics have conducted studies and found out that psychotropic medications do more harm than good. Psychotropic medication is commonly used to control problematic behaviors of patients with mental health complications. However, the study by Valdovinos et al. (2016) on the effects of psychotropic medication on controlling problematic behaviors of mentally challenged individuals found contrary outcomes. The researchers examined eight patients in two years and observed changes in psychotropic medication combinations. The study found out that the adjustment of psychotropic medication produced changes in functional evaluation outcomes. However, their behaviors varied significantly in all the medication adjustments. Moreover, three of the patients exhibited inconsistent medication changes thus implying that not all psychotropic medication regimes produce behavior changes (Gareri et al., 2014). Psychotropic medication in psychiatric senior adults have also been found to cause obesity and obesity-related complications. For example, clozapine and olanzapine have been attributed to an increased risk of weight gain. A systematic review conducted by Almandil et al. (2013) on the metabolic severe effects and weight gain in children and adolescents due to the use of psychotropic treatment. The study found out that there was an average increase in weight for each psychotropic drug consumed. For example, the intake of olanzapine resulted in an increase
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MENTAL HEALTH5 in weight by 3.45 kg (95 % CI 2.93–3.98). Eight other studies reported a substantial metabolic abnormality such as an increase in prolactin with risperidone. Another common side effect of the use of psychotropic medications on patients with Schizophrenia is metabolic-related complications. Yogaratnam, Biswas, Vadivel, and Jacob (2013) found out that second-hand generation anti-psychotropic drugs produce severe effects that increase the risk of metabolic complications. The continued use of psychotropic medication has also been found to increase the risk of hypertension. The study by Ott et al. (2019) found out that selective serotonin reuptake inhibitors and olanzapine accounted for the increased risk of developing hypertension within six months after initial medication. Moreover, Olanzapine was substantially linked to diabetes six months after the initial prescription The prevalent use of psychotropic medication in the treatment of mental health conditions in children, adolescents and adults has been associated with aggressive and suicidality behaviors. A systematic review of the severe side effects of selective serotonin and serotonin- norepinephrine reuptake inhibitors was carried out (Sharma, Guski, Freund, & Gøtzsche, 2016). The study reported over 155 incidences of suicidality with an odds ration being 1.21 (95% confidence interval 0.84 to 1.74). Patients administered with duloxetine manifested aggressive behaviors. The use of antidepressants across all ages doubly increased the risk of aggressive behavior. Similar findings were arrived at by Witt, Van Dorn, and Fazel (2013) who reported 18.5% incidences of violence but attributed this to factors such as non-adherence to medication, recent drug abuse, and poor control of emotions. The death of over five hundred thousand people aged 65 years and above in the Western world is attributable to the long-term use of psychotropic drugs. An assessment for the evidence of the high death rate after antipsychotic medication for dementia patients was carried out. The
MENTAL HEALTH6 study was prompted by the increased use of antipsychotic drugs for the treatment of delusions, hostility, and anxiety in patients with dementia. The study found out that there was a higher mortality rate among patients randomized to medications such as aripiprazole, risperidone among others (Maust et al., 2015). The cumulative exposure to antidepressant medication and mortality rate was examined by Tiihonen et al. (2016) who found out that the average use of psychotropic medications resulted in a lower death rate. However, the use of benzodiazepines was associated with death (hazard ratios up to 1.74 [95% CI=1.50–2.03]). The Controversy Over the Use of Psychotropic Medications in Psychiatric Settings Both the proponents and opponents of psychotropic medications have justifications for their position. Thus, there are conflicting arguments on both sides. The opponents of psychotropic medication contend that the long-term use of psychotropic medication and approval from regulatory bodies is not sufficient grounds for adopting the medications. Gøtzsche (2015) argues that the effects of psychotropic medication should be observed over time and the decision made based on the outcomes of the patients. Critics of psychotropic medication argue that the benefits are overstated and the deaths understated. For instance, the randomized control trials on the benefits of psychotropic drugs have not properly been carried out. A significant number of the studies are biased because they examine patients under the prescription of other drugs (Tan et al., 2015). Contenders of the benefits of psychiatric medication also argue that the mortality rates are under-reported. For example, the funded clinical trials cited by the US Food and Drug Administration had over 15 incidences of suicides among individuals taking antidepressants contrary to those reported by the FDA (Gøtzsche, 2015). On the other hand, the proponents of psychotropic medication argue that the deteriorating health of individuals with psychiatric
MENTAL HEALTH7 conditions can be caused by the effects of the diseases alone even without medication. Additionally, the high mortality and suicidality rates among psychiatric patients is caused by the coexisting physical health complications and not medications (Gøtzsche, Young, & Crace, 2015). Challenges Experienced by Registered Nurses Administering Psychotropic Medications Nurses who take care of patients with mental illness conditions experience multiple challenges when administering psychotropic drugs to manage and regulate their challenging behaviors. Nurses face patient aggression and risk of arm in mental care settings. Multiple empirical studies have explored the challenges experienced by mental healthcare nurses. Dack et al. (2013) conducted a review and meta-analysis on the factors that influence patient aggression in mental healthcare settings. The study reported that patients that were forcefully admitted and that had a history of drug and substance abuse were more aggressive to nurses than others. Similar findings were arrived at by Iozzino et al. (2015) who observed that the risk of aggression and harm was high among psychiatric patients with a history of drug and substance abuse. A study conducted on the determinants of burnout in mental health experts reviewed 62 studies obtained from MEDLINE/PubMed, Embase databases and found out that nurses in mental health care settings experienced significant burn out during diagnosis and medication of patients. 40% (CI 31%–48%) of the nurses cited mental exhaustion low self-esteem due to unaccomplished tasks 19% (CI 13%–25%) (O’Connor, Neff, & Pitman, 2018). Working with mentally ill patients also poses the challenge of poor diagnosis due to lack of cooperation from the unwilling patients, high incidences of sick leave because of distress
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MENTAL HEALTH8 Psychiatric nurses have also been found to be the most affected by drug and substance abuse owing to the nature of their work. A study used anonymous surveys and examined 441 healthcare professionals that were active in a peer health program. The researchers assessed drug-associated conduct at the workplace among other cues. 48% of the nurses admitted using drugs or alcohol at work and attributed such behavior to poor performance (Cares, Pace, Denious, & Crane, 2015). The act of drug and substance use among psychiatric nurses was further explored by McTiernan, and McDonald (2015) the authors noted that the experience of handling violent psychiatric patients did not affect the wellbeing of the patients only but the nurses undertaking the medication and those witnessing. Since nurses are human beings with feelings but are still expected to take care of violent patients, they resorted to the use of drugs to benumb their feelings and thus affecting their health and work as well. Conclusion Psychotropic medication has been applauded as an effective approach in the regulation of behaviors and management of symptoms in a psychiatric setting. Some of its benefits include low risk of overdose, low death rate, improved quality of life, lower suicide rates. On the other hand, the psychotropic drugs have been found to produce more harm than good. They are responsible for obesity, weight gain, adverse metabolic rates, high mortality rate, hypertension, and aggressive behaviors. Nurses in mental healthcare settings are equally affected when administering psychotropic medication. Some of the effects include depression, burnout, aggression, increased risk of self-harm and drug and substance abuse. It is evident there exists a conflict on whether the benefits of psychotropic medication outweigh the harms and vice versa.
MENTAL HEALTH9 There is, therefore, a need for more thorough research on the same so as to decide on whether to continue using the drugs or to discard them completely and find another alternative.
MENTAL HEALTH10 References Almandil,N. B., Liu, Y., Murray, M. L., Besag, F. M., Aitchison, K. J., & Wong, I. C. (2013). Weight gain and other metabolic adverse effects associated with atypical antipsychotic treatment of children and adolescents: a systematic review and meta-analysis.Pediatric Drugs,15(2), 139-150. Angst, J., Hengartner, M. P., Gamma, A., von Zerssen, D., & Angst, F. (2013). Mortality of 403 patients with mood disorders 48 to 52 years after their psychiatric hospitalisation.European archives of psychiatry and clinical neuroscience,263(5), 425- 434. Cares, A., Pace, E., Denious, J., & Crane, L. A. (2015).Substance use and mental illness among nurses: Workplace warning signs and barriers to seeking assistance.Substance Abuse,36(1), 59-66. Columbia University Medical Center. (2017, May 5). Benefits of antipsychotics outweigh risks, find experts.ScienceDaily. Retrieved April 9, 2020 from www.sciencedaily.com/releases/2017/05/170505085003.htm Dack,C., Ross, J., Papadopoulos, C., Stewart, D., & Bowers, L. (2013). A review and meta‐ analysis of the patient factors associated with psychiatric in‐patient aggression.Acta Psychiatrica Scandinavica,127(4), 255-268. Gareri, P., Segura-García, C., Manfredi, V. G., Bruni, A., Ciambrone, P., Cerminara, G., De
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MENTAL HEALTH11 Sarro, G., & De Fazio, P. (2014). Use of atypical antipsychotics in the elderly: a clinical review.Clinical interventions in aging,9, 1363–1373. https://doi.org/10.2147/CIA.S63942 Goff,D. C., Falkai, P., Fleischhacker, W. W., Girgis, R. R., Kahn, R. M., Uchida, H., ... & Lieberman, J. A. (2017). The long-term effects of antipsychotic medication on clinical course in schizophrenia.American Journal of Psychiatry,174(9), 840-849. Gordon, M., & Melvin, G. (2013).Selective serotonin re-uptake inhibitors: a review of the side effects in adolescents.Australian family physician,42(9), 620. Gøtzsche, P. C. (2015).Deadly psychiatry and organised denial. Art People. Gøtzsche, P. C., Young, A. H., & Crace, J. (2015).Does long term use of psychiatric drugs cause more harm than good?.BMJ (Clinical research ed.),350, h2435. https://doi.org/10.1136/bmj.h2435 Iozzino, L., Ferrari, C., Large, M., Nielssen, O., & De Girolamo, G. (2015). Prevalence and risk factors of violence by psychiatric acute inpatients: a systematic review and meta- analysis.PloS one,10(6). Maust,D. T., Kim, H. M., Seyfried, L. S., Chiang, C., Kavanagh, J., Schneider, L. S., & Kales, H. C. (2015). Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm.JAMA psychiatry,72(5), 438-445. McTiernan, K., & McDonald, N. (2015). Occupational stressors, burnout and coping strategies
MENTAL HEALTH12 between hospital and community psychiatric nurses in a D ublin region.Journal of psychiatric and mental health nursing,22(3), 208-218. O’Connor, K., Neff, D. M., & Pitman, S. (2018).Burnout in mental health professionals: A systematic review and meta-analysis of prevalence and determinants.European Psychiatry,53, 74-99. Ott, M., Mannchen, J. K., Jamshidi, F., & Werneke, U. (2019). Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques.Therapeutic advances in psychopharmacology,9, 2045125318818814.https://doi.org/10.1177/2045125318818814 Qin, B., Zhang, Y., Zhou, X., Cheng, P., Liu, Y., Chen, J., ... & Xie, P. (2014). Selective serotonin reuptake inhibitors versus tricyclic antidepressants in young patients: a meta- analysis of efficacy and acceptability.Clinical therapeutics,36(7), 1087-1095. Sharma, T., Guski, L. S., Freund, N., & Gøtzsche, P. C. (2016).Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports.bmj,352. Sheehan,R., Hassiotis, A., Walters, K., Osborn, D., Strydom, A., & Horsfall, L. (2015). Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study.Bmj,351, h4326. Tan,L., Tan, L., Wang, H. F., Wang, J., Tan, C. C., Tan, M. S., ... & Yu, J. T. (2015).
MENTAL HEALTH13 RETRACTED ARTICLE: Efficacy and safety of atypical antipsychotic drug treatment for dementia: a systematic review and meta-analysis.Alzheimer's research & therapy,7(1), 20. Tiihonen,J., Mittendorfer-Rutz, E., Torniainen, M., Alexanderson, K., & Tanskanen, A. (2016). Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: an observational follow-up study.American Journal of Psychiatry,173(6), 600-606. Valdovinos, M. G., Henninger-McMahon, M., Schieber, E., Beard, L., Conley, B., & Haas, A. (2016). Assessing the impact of psychotropic medication changes on challenging behavior of individuals with intellectual disabilities.International journal of developmental disabilities,62(3), 200-211. Vermeulen, J., van Rooijen, G., Doedens, P., Numminen, E., van Tricht, M., & de Haan, L. (2017). Antipsychotic medication and long-term mortality risk in patients with schizophrenia; a systematic review and meta-analysis.Psychological medicine,47(13), 2217-2228. Witt, K., Van Dorn, R., & Fazel, S. (2013).Risk factors for violence in psychosis: systematic review and meta-regression analysis of 110 studies.PloS one,8(2). Yogaratnam, J., Biswas, N., Vadivel, R., & Jacob, R. (2013).Metabolic complications of schizophrenia and antipsychotic medications-an updated review.East Asian Archives of Psychiatry,23(1), 21.