PHARMACOLOGY ASSIGNMENT
2
Fluoxetine is an antidepressant drug that is responsible for the selective reuptake inhibitor of
serotonin; thus, it inhibits the production of serotonin the brain to a certain extent. Thus, the
noradrenaline is produced in a higher amount (Castillo et al., 2018). On the other hand,
Nortriptyline is a noradrenaline selective reuptake inhibitors; thus, it inhibits the
noradrenaline production in the brain result; it just the opposite reaction as that of Fluoxetine.
5. Triazolam and Ramelteon
Triazolam is a short-acting benzodiazepine that is being metabolised in a hepatically manner
through the oxidative pathway. The pharmacological effects of the drug are to enhance the
neurotransmitter GABA at the GABAA receptor. Conversely, Ramelteon binds to the MT1
and MT2 receptors in the suprachiasmatic nucleus instead of binding to the GABAA receptor
and is a sleep agent medicine (Biswas, et al., 2019).
6. Buspirone and Fluoxetine
Buspirone is an anxiolytic and hypnotic drug that has a high affinity to serotonin. It acts as an
agonist of the serotonin 5-HT1A receptor and has a full agonist of the presynaptic 5-HT1A
receptor. This drug inhibits autoreceptors and is a partial agonist of the postsynaptic 5-HT1A
receptor. Fluoxetine is a drug that blocks the serotonin reuptake transporter in the presynaptic
end and thus, results in a sustained level of 5-HT in certain parts of the area.
7. Amoxicillin and Pyrazinamide
Amoxicillin is an inhibitor of penicillin-binding protein 1 as well as other penicillin-binding
proteins. Thus, it inhibits the action id glycosyltransferase and transpeptidase reaction in the
body. In this case, the bacteria upregulates the autolytic enzyme as a result; they are unable to
build and repair the cell wall. Pyrazinamide acts in M. tuberculosis by expression of
pyrazinamidases and inhibits the activity if purified FAS (Drugbank.ca, 2020).

Pharmacology GABAA Assignment 2022

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