Pharmacology GABAA Assignment 2022

Running head: PHARMACOLOGY ASSIGNMENT
PHARMACOLOGY ASSIGNMENT
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PHARMACOLOGY ASSIGNMENT
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Answer 1
The ten unique pair of drugs whose action oppose each other are:
1. Ropinirole and Pimozide
Ropinirole is a drug that is used for treating Parkinson disease and it acts by increasing the
dopamine level in the body. On the other hand, Pimozide is a typical antipsychotic drug that
to the class of the diphenylbutylpiperidine and act on reducing the level of dopamine in the
human body.
2. Tranylcypromine and Fluoxetine
Tranylcypromine and Fluoxetine are both belonging to the antidepressant drug; however,
both have different target and mechanism of action. As per the opinion of Ferreira-Garcia et
al. (2018), Tranylcypromine that acts as a nonselective and irreversible inhibitor of the
enzyme monoamine oxidase (MAO) thus help in restoring certain natural substances such as
neurotransmitters in the brain. On the other hand, Fluoxetine is stated to be a selective
serotonin reuptake inhibitor, thus, inhibit the action of uptake of serotonin in the body and
treat depression, obsessive-compulsive disorder as well as bulimia.
3. Imipramine and Mirtazapine
Imipramine is a tricyclic antidepressant drug that is used for the treatment of depression. The
drug act as a nonselective reuptake inhibitor, thus, helps in treating disorders related to a
panic attack and anxiety. Mirtazapine is a group of antidepressant drug that acts as
nonselective release enhancers that involve reuptake of hormones such as serotonin and
noradrenaline that are stated to be mood-enhancing chemicals in the brain.
4. Fluoxetine and Nortriptyline

PHARMACOLOGY ASSIGNMENT
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Fluoxetine is an antidepressant drug that is responsible for the selective reuptake inhibitor of
serotonin; thus, it inhibits the production of serotonin the brain to a certain extent. Thus, the
noradrenaline is produced in a higher amount (Castillo et al., 2018). On the other hand,
Nortriptyline is a noradrenaline selective reuptake inhibitors; thus, it inhibits the
noradrenaline production in the brain result; it just the opposite reaction as that of Fluoxetine.
5. Triazolam and Ramelteon
Triazolam is a short-acting benzodiazepine that is being metabolised in a hepatically manner
through the oxidative pathway. The pharmacological effects of the drug are to enhance the
neurotransmitter GABA at the GABAA receptor. Conversely, Ramelteon binds to the MT1
and MT2 receptors in the suprachiasmatic nucleus instead of binding to the GABAA receptor
and is a sleep agent medicine (Biswas, et al., 2019).
6. Buspirone and Fluoxetine
Buspirone is an anxiolytic and hypnotic drug that has a high affinity to serotonin. It acts as an
agonist of the serotonin 5-HT1A receptor and has a full agonist of the presynaptic 5-HT1A
receptor. This drug inhibits autoreceptors and is a partial agonist of the postsynaptic 5-HT1A
receptor. Fluoxetine is a drug that blocks the serotonin reuptake transporter in the presynaptic
end and thus, results in a sustained level of 5-HT in certain parts of the area.
7. Amoxicillin and Pyrazinamide
Amoxicillin is an inhibitor of penicillin-binding protein 1 as well as other penicillin-binding
proteins. Thus, it inhibits the action id glycosyltransferase and transpeptidase reaction in the
body. In this case, the bacteria upregulates the autolytic enzyme as a result; they are unable to
build and repair the cell wall. Pyrazinamide acts in M. tuberculosis by expression of
pyrazinamidases and inhibits the activity if purified FAS (Drugbank.ca, 2020).