The paper is structured to talk about the three theories that integrate stress, the way these theories focus on the clinical approaches, the way it controls the patient outcome, various ways the theories can be used for addressing clinical issues and the challenges faces by the nurses. There are different ways theories were developed thus implying strong influence of the stress management. The stimulus-based stress theory defines that can awaken different psychosomatic reactions, which can additionally enhance the individual's susceptibility towards different diseases (Papathan