Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation in Young, Healthy Adults

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Added on 2019-11-20

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Measures 3T Allegra magnetic resonance imaging T1-weighted three-dimensional-MPRAGE imaging Motion correction using PACE (Siemens) Mean intensity normalization LTRRW, LTRSD, PLUSRW, PLUSSD used for functional analysis Region of interest based analysis Results Behavioral results- Increased ESS showed greater subjective sense of sleepiness after SD. Activation after SD when compared to RW- PLUS and LTR showed activation in overlapping regions after SD than during RW. Larger post SD increase in BOLD signal observed in left

Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation in Young, Healthy Adults

Added on 2019-11-20

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Notes for paper: Functional Imaging of Working Memory after 24 Hr of Total SleepDeprivation (Chee &Choo, 2004).Aim(s)To examine the interaction between task complexities and state that modulatescortical activation in young, healthy adults during working memory tasks.Participantn= 14 right handed, young, healthy adults (mean age- 23 years).male- 9, female- 5.Study DesignVolunteers with good sleep patterns.Average sleep of 7.2 +/- 0.9 hours per night.No volunteers included with history of insomnia, daytime sleepiness, psychiatricillness, narcolepsy or addicts.Protocol SD and RW scanning of subjects conducted within 1 week.Subjects abstained from caffeine, smoking, for 24 hr before scanning. Alcohol wasdisallowed.Engaged in non-strenuous activities like conversing and video watching. Epworth sleepiness scale (ESS) used to rate sleepiness and simple reaction time task(SRT) performed.180 trials executed.Measures

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3T Allegra magnetic resonance imagingT1-weighted three-dimensional-MPRAGE imagingMotion correction using PACE (Siemens)Mean intensity normalization LTRRW, LTRSD, PLUSRW, PLUSSD used for functional analysisRegion of interest based analysisResults Behavioral results-Increased ESS showed greater subjective sense of sleepiness after SD. Responses omitted after SD not for PLUS but for LTR.Slow RT for both PLUS and LTR.RW activation-Left hemisphere dominant activation observed in LTR in prefrontal (pre-central regions, insula, Brodman’s area and thalamus).Areas showed more activation in PLUS than LTR. These areas were left prefrontal region around left insula, left inferior parietallobule, middle frontal gyrus and bilateral thalamus.No region more activated in LTR compared to PLUS. Cortical deactivation lesser for LTR than PLUS in RW.Activation after SD when compared to RW-PLUS and LTR showed activation in overlapping regions after SD than duringRW.LTR and PLUS elicited smaller task related BOLD signal by Voxel-by-voxelanalysis in the parietal region when compared to RW.

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