In most cases of type 2 diabetes, cells in muscle, fat, and the liver become resistant to insulin. Insulin doesn't interact normally with these cells, so they don't take in enough sugar. Insufficient insulin is produced by the pancreas to control blood sugar levels. Diabetes mellitus patients need to have their symptoms eliminated and have complications prevented or at least slowed down. In type 2 diabetes mellitus, there is hyperglycemia as a consequence of insulin resistance, insufficient insulin secretion, and excessive or inappropriate glucagon release.