Pathophysiology of Asthma: Causes, Symptoms, and Management

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Client details
 Name: Philip Nguyen
 Gender: Male
 Age: 15 years
 Condition: Asthma
 Healthy weight: Yes
 Exercise: Wishes he would play more sport
 Occupation: Student
 Living status: stays with parents and two younger sisters
 Family medical history: Nothing relevant
 Pregnancy: NA
 Smoking: Tried smoking few times
 Alcohol intake: N/A
 Current medication: Salbutamol

Pathological changes-Bronchial
smooth muscle contraction
 Triggering factors such as
cigarette smoke, dust and pollen
grains reach the
airways(Rogliani, Ora, Puxeddu,
& Cazzola, 2016).
 They then bind to mast cells.
 The mast cells disintegrate to
produce mediators basically
histamine.
 Histamine then stimulates
contraction of the smooth
muscles making the airways to
become narrow(Sullivan, Hunt,
MacSharry, & Murphy, 2016).
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Increased mucus
production
 Contraction of smooth muscles and narrow
airways leads to swelling of the mucus lining.
 Inflammation leads to production of cytokines that
stimulate production of mucus(King, James,
Harkness, & Wark, 2018).