Zidovudine the drug trial: Ethical concerns in drug trials of Zidovudine

Zidovudine the drug trial

Table of Contents
INTRODUCTION...........................................................................................................................3
MAIN BODY...................................................................................................................................3
CONCLUSION................................................................................................................................7
REFERENCES................................................................................................................................8

INTRODUCTION
Zidovudine refers to medication that has high potential to provide treatment for the
human immunodeficiency virus (HIV) infection through with other medication. This medication
provides to pregnant women with HIV-positive symptoms. This can help to reduce the chances
of passing infection within the baby. In the mid 1990’s there was a controversy regarding this
which create a situation of ethical concern. Here, Placebo-controlled studies include the way of
testing of medication therapy which includes the group of participants that were receiving the
treatment which was needed to evaluate where one group get the placebo treatment that has the
specification of no real effect. Here, this effect is a difficult concept that leads to deal with when
any individual does not recognize the order to control it. The placebo used in the clinical trials
which includes the test of effeteness within treatment that are often used during the studies. In
this essay, there is a discussion about the controversy which was due to ethical consideration
about the drug trials that was conducted within different developing countries (Barat, (2021)).
MAIN BODY
Zidovudine (ZDV) also known as the azidothymidine (AZT) which is an antiretroviral
medication which are effective in preventing and treating HIV/AIDS. It is generally
recommended and can have used in combination with other antiretrovirals. This drug has the
potential to prevent the spread of infection which can resist getting it from mother to child during
birth. There was the drug trial that indicates the effectiveness which included different ethical
considerations. Here, there are much information that can reflect the drug trial as unethical
practices (McHenry et. al., (2019)). This was the one that created high effectiveness of the drug
where the trail was done on a large number of participants but due to not using of the drug on all
the participants leads to create the situation of not ethical trail where involvement of the trail
includes the difference to the unethical practices within the drug trial. Here, this drug trial
includes unethical practices which are associated with providing Zidovudine to all the
participants which was not the correct practice within the drug trial (Orient, (2020)).
There was an unethical concern that was related with informed consent. This is the one
which includes the population that were not the vulnerable people like old, poor, children or
mentally impaired. In this, there was need of consent from the participants but due to not having
the proper reach and research conduction was necessary to ensure about the effectiveness of the