7304MED Health Care Systems Reading Log: PrEP Analysis

This reading log assignment analyzes a research paper on preexposure prophylaxis (PrEP) for HIV prevention within a large integrated health care system. The assignment requires the student to summarize the main thesis, findings, accuracy, reliability, and validity of the study. It also includes an assessment of the generalizability of the findings to the wider community, personal agreement or disagreement with the paper's conclusions, and the paper's overall usefulness. The student's analysis focuses on factors such as PrEP adherence, renal safety, and discontinuation, as well as the impact of the study on guidelines for STI screening and the importance of addressing social factors like insurance coverage. The paper highlights the efficacy of PrEP in reducing HIV seroconversion and discusses the need for long-term studies and community health program implementation.

7304MED HEALTH CARE SYSTEMS - READING LOG TEMPLATE
Student Name:
Student Number:
Criterion Response to Criterion
Correct Citation (in
APA6 format)
Marcus, J. L., Hurley, L. B., Hare, C. B.,
Nguyen, D. P., Phengrasamy, T.,
Silverberg, M. J., ... & Volk, J. E.
(2016). Preexposure prophylaxis for
HIV prevention in a large integrated
health care system: adherence, renal
safety, and discontinuation. Journal
of acquired immune deficiency
syndromes (1999), 73(5), 540.
McCormack, S., Dunn, D. T., Desai, M.,
Dolling, D. I., Gafos, M., Gilson, R., ...
& Mackie, N. (2016). Pre-exposure
prophylaxis to prevent the
acquisition of HIV-1 infection
(PROUD): effectiveness results from
the pilot phase of a pragmatic open-
label randomised trial. The
Lancet, 387(10013), 53-60.
What is the main
thesis of the paper
The objective of the paper is to identify
the efficacy of preexposure prophylaxis
(PrEP) in preventing HIV, based on
associated factors that motivate patient to
adopt PrEP (Marcus et al., 2016).
What are the main
findings of the
work?
PrEP usage have consistent effect in
reducing HIV seroconversion cases.
Discontinuation of PrEP is not due to renal
toxicity, but because of loss of insurance
coverage and specific race of Blacks, and
among drug abuse disorder people.
How are you
assured of accuracy
within the paper
The results are based on 850 person-years
of PrEP and clinical outcomes are
measured before and after PrEP. The
analysis are based on sex, ethnicity,

Criterion Response to Criterion
clinical consideration, and results were
concluded with identification of HIV
seroconversion cases. The complete
analytical details including number of
participants and their categorization
details, assure the accuracy within the
paper.
How are you
assured of
Reliability of the
measurements
used in the paper
The clinical outcomes were assessed using
statistical methods having level of
confidence 0.005 or alpha value < 0.001,
which assured the reliability of
measurements.
How are you
assured of the
Validity of the
results
Clinical results of PrEP adherence were
known, which motivates the author to
collect real-world data (McCormack et al.,
2016). The results were similar that PrEP
prevent HIV seroconversion with minimal
renal toxicity. Moreover, the results were
validated with statistical inference.
Can the findings be
generalized to the
wider community?
The findings are important for:
implementing change in guidelines for STI
screening, black people and women are
required to provide education about PrEP
importance, and social factors like
insurance coverage issues that is
responsible for discontinuation must be
resolved.
Describe what you
agree with and/or
what you disagree
with in the paper.
Agree: PrEP is useful in controlling HIV
infection.
Disagree: The long term usage must be
tested, which can confirmed the time-
period upto which PrEP is effective in
preventing HIV seroconversion. Hence,
mere finding that PrEP control HIV, is not
sufficient, rather duration of efficiency is
also important.
How useful (or not) The paper is useful because PrEP usage

Criterion Response to Criterion
was the paper and
why have you
reached this
conclusion?
can be recommended in community
health programs. The paper was selected
because it shed light on the efficacy of HIV
prophylactic drugs and associated side
effects.
*Use the definitions provided in the assessment instructions for each criteria listed in the left hand
criterion column of this template to guide your response to the criterion.
**To calculate your word limit, please be advised that this template contains 100 words when blank